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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Like Idols for scientists
2014-04-10

Kovsie student and scientist Karabelo Moloantoa recently represented the Free State in the South African finals of the FameLab competition during the Sci-Fest in Grahamstown.

Karabelo is a 24-year-old student doing his master’s in Biotechnology. He completed his Bachelor’s degree in Medical Microbiology, as well as his Honours degree in Biochemistry at Kovsies. His research is focused on Bioremediation of mine waste waters.

“FameLab is like the scientists Idols taking place annually,” says Karabelo.

“In the competition we are given three minutes to explain a science aspect to a non-science audience. There are 25 countries that participate. South Africa is the only African country participating.”

“I was called by one of my lecturers an hour before the local competition took place at the National Museum in Bloemfontein. I was actually still tired from playing volleyball the night before,” he explains. “I was unprepared and without slides, but I did my presentation.”

This was the first year Karabelo entered FameLab and although he was somewhat unprepared for the local competition in Bloemfontein, he was nominated to represent the Free State in Grahamstown at the Sci-Fest event. From the 18 semifinalists, Karabelo qualified to go the finals where the 9 finalists were competing to represent South Africa in the United Kingdom for the international finals.

“I did not win the UK trip, but I made it to the finals, which is an achievement as half of the semi-finalists could not make it to the finals,” says Karabelo.

“I feel like I have done well to represent the university and the province as a whole. It was amazing to speak in front of more than 800 people, delivering my presentation. I learnt a lot and improved my skills of communicating scientific aspects. I will definitely enter again next year.”

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