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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

OSM Camerata records CD with world-renowned cellist
2014-05-14

In 2010, South African cellist Heleen du Plessis, Executant lecturer for cello at the University of Otago, initiated the project “Cello for Africa”. The objective was to record a CD of new South African compositions for cello, reflecting the multi-cultural context of the country.

Du Plessis received an extensive research grant from the University of Otago in order to realise the project by commissioning, premièring and recording music. The aim was to facilitate a dialogue between Western and African musical traditions, as well as between the cello and indigenous African instruments.

Hans Huyssen, composer and cellist, has been closely involved in indigenous African music for a considerable time. In light of his extensive international experience, the SAMRO Foundation has granted Du Plessis' request to commission Huyssen to this task.

A world premiere concert preceded the recordings at the UFS’ Odeion School of Music (OSM) in March 2013, partially funded by a Humanities Research Grant as well as the OSM. This event provided a collaborative platform for musicians from different cultural backgrounds and several institutions to contribute towards a cultural and musical exchange. The funding enabled the project to successfully conclude in the recording of the CD, “Cello for Africa”. It was released by ODE records – the New Zealand label for classical music.

The OSM Camerata (OSMC) is the flagship ensemble of the OSM and was founded in 2012 with the main objective to kindle and forge the talents of exceptionally gifted students and pursue the highest artistic standards possible.

The OSMC participated in 2013 in the 13th International Conservatoire Festival hosted at the Rimsky Korsakov Conservatoire in St Petersburg, Russia. The OSMC received a standing ovation during their gala performance in the Glazonov Hall with a programme by South African composers Stefans Grové and Hendrik Hofmeyr.

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