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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Honouring Stanley Trapido – one of the most influential historians South Africa has produced
2014-08-14

 

Prof Charles van Onselen
Photo: Supplied

The International Studies Group and the History Department at the UFS hosted a seminar on Stanley Trapido by Prof Charles van Onselen on Monday 11 August 2014.

The seminar honoured the life and work of Trapido, one of the most important and influential historians South Africa has ever produced.

Trapido is probably best known for his work on the causes and consequences of the South African War of 1899–1902. It was to this broad time period that Prof Van Onselen spoke in his paper ‘The Political Economy of the South African Republic, 1881–1895’.

Prof Van Onselen’s lecture provided a major reinterpretation of the origins and causes of the Jameson Raid while emphasising that Paul Kruger’s ZAR was a state beset by crime and corruption. It was particularly fitting that Prof Van Onselen gave the inaugural seminar paper, since Trapido supervised his Oxford doctoral thesis.

The International Studies Group and the History Department were extremely honoured by Trapido’s widow, the Booker Prize nominated author Barbara, attending the seminar. They wish to thank her for donating her husband’s academic library to the UFS.

Following the Sharpeville massacre of 1960, the Trapido-couple emigrated to England. While there, Trapido began to shape what is now known as the ‘revisionist’ school of South African historiography. He argued the importance of analysing capital and class formation, which he maintained informed the racial ideologies that culminated in apartheid.

Prof Van Onselen’s inaugural seminar presentation will be followed later this term by papers from David Moore, Sabelo Ndlovu-Gatsheni and Giacomo Macola.

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