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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Weak states and armed movements – researching the underlying links
2014-08-28

 

Prof Theo Neethling is conducting research on armed movements in the DRC.
Photo: en.wikipedia.org

Prof Theo Neethling from the Department of Political Studies and Governance is currently conducting research on armed movements in the Democratic Republic of the Congo (DRC).

“My research is premised on the scholarly insight and argument that in weak states, such as the DRC, armed movements and militias are filling power vacuums that are the result of the inability and lack of military capacity to fight these movements effectively,” Prof Neethling says.

“In this context, the DRC is severely affected by sub-state terrorism,” he continues.

“This is a phenomenon that is intimately linked to the failure to effect sustained development and to consolidate accountable and effective governance in especially the eastern provinces of the country.”

Earlier this year, Prof Neethling presented conference papers on this topic at two international conferences: the Conference of the New York State Political Science Association, as well as the World International Studies Conference hosted in Frankfurt, Germany.

In 2013, Prof Neethling co-edited the book, ‘Post-Conflict Reconstruction and Development in Africa: Concepts, Policy, Role-players and Practice’. He completed this work in collaboration with Prof Heidi Hudson from the UFS Centre for Africa Studies.

“The book revolves around the concept of ‘post-conflict’ and the blurring of military and civilian roles, analysing the multiple roles of the United Nations in the DRC and Sierra Leone, as well as the African Union Mission in Burundi,” Prof Neethling says.

“It also explores South Africa’s foreign policy imperatives in relation to multinational peace missions in conflict-stricken African states, involving military as well as civilian role-players.” 
 
 
 
 
 

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