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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Work clouds and rhizomatic learning – Prof Johannes Cronjé teaches through technology in inaugural lecture
2014-09-29

Prof Johannes Cronjé 

Prof Johannes Cronjé has been appointed as visiting professor in the Faculty of Natural and Agricultural Sciences in collaboration with the Centre for Teaching and Learning. The driving force behind his appointment is to develop young and upcoming scholars in the field of online and blended learning at our university.The title of Prof Cronjé’s inaugural lecture, ‘Tablets, Painkillers or Snake Oil – a Remedy for Education?’ suggested a compelling event. Prof Cronjé did not disappoint.

“We live in a world where we carry more information in our pockets than in our entire head,” Prof Cronjé remarked. Interesting fact: an iPhone 4 has 16 million times more processing power than the Apollo 11 – the spacecraft that put the first man on the moon.

If students carry this much processing power in their hands, what should we be teaching students? Prof Cronjé asked. “I believe the answer to that is: we should be teaching them to teach themselves.”

Presenting his inaugural lecture in the same way as he would to his students, Prof Cronjé had the entire audience within minutes vigorously participating in the event.

Prof Cronjé advocates a process called rhizomatic learning. Knowledge, he explained, grows in a similar way to rhizomes’ roots – inseparably connected and seemingly without beginning or end. “Learning is a social aspect: people learn from one another.”

Making use of freely-available online applications, Prof Cronjé demonstrated the power of technology in the classroom. “My objective is to use technology to make people enthusiastic and motivated about the learning process.” Using their smartphones, tablets and laptops, the audience could effortlessly participate through connecting to each other by means of a virtual work cloud. “Knowledge is being created in the room as it happens,” Prof Cronjé explained, “motivating you to participate in this learning experience.”

“There are three things you need for group work to be successful: a mutual goal, individual responsibility and positive interdependence. Then it is real cooperative learning,” Prof Cronjé concluded.

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