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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Latest information technology employed to make learning in Disaster Management easy
2014-10-20



Prof Dusan Sakulski
Photo: Leonie Bolleurs
Live, colourful, interactive, real-time-calculated. This is how Prof Dusan Sakulski, researcher and lecturer from the UFS’s Disaster Management Training and Education Centre for Africa (DiMTEC), describes his e-learning platform implemented in this department.

Rather than producing research that gathers dust somewhere in a cabinet, Prof Sakulski believes that research should be used to make life easier, not only for society, but also for his students.
 
This educational civil engineer, who is responsible for information technology implementation in disaster risk management, developed through his research several programs to optimise the three contact sessions DiMTEC students have to attend each year.
 
One of the initiatives implemented by Prof Sakulski and his daughter Teodora, was the recording, editing and compiling of theoretical lessons and making it available to students online. “Students then don’t have the excuse of missing a class. Furthermore, it allows them to rather focus on group work during contact sessions and to discuss problems they encountered with the work,” he says.
 
Students also have access to an early-warning system portal for the prediction of hazards, including droughts, floods, rain and temperature. In the disaster-risk environment, this program is very useful, not only for students, but also for practitioners working with this kind of data on a daily basis. The operational and educational application works in real time – with the click of a mouse students and practitioners have access to information on current weather conditions. Indicators for possible natural disasters are also built into this program. Truly a useful application when you are working in the field of disaster risk management.

Difficult and technical data are presented live, with information that is colourful, interactive, real-time-calculated and audible, thanks to embedded mathematical language. In this way, students can learn, memorise and understand their work better.


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