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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

The mysterious origins and problematic significance of the Postamble
2014-10-20



Prof André du Toit (UCT) and Prof Pieter Duvenhage (UFS)
Emeritus professor from UCT’s Department of Political Studies, Prof André du Toit, delivered a presentation at the Bloemfontein Campus on 14, 15 and 16 October 2014 respectively. His presentations gave an in-depth exploration of the Postamble as founding text of the South African Truth and Reconciliation Commission (TRC).

This event was hosted by the Institute for Reconciliation and Social Justice, in collaboration with the Department of Philosophy.

Prof Du Toit’s papers were entitled:
•    A Need for Truth: Amnesty and the Origins and Consequences of the TRC Process.
•    Tracking down a belated and inconclusive amnesty pact: The obscure origins and problematic significance of the 'Postamble' as founding text of the TRC process (Part 1 and 2).

In his presentations he explored how the text of the Postamble came to be written. He also scrutinised the respective contributions of those who were involved in drafting the text. The significance of the Postamble – as it is understood in its historical context – was also a point of discussion.

Prof Du Toit raised some thought-provoking questions during the three days. What is the relation of the amnesty provision of the Postamble with the subsequent TRC amnesty process? How did a text without any particular reference to a truth commission come to function as founding text and discursive framework for the TRC?

He also investigated some of the main problems with the history and significance of the Postamble, as well as its mysterious origins. In addition, Prof Du Toit conducted a critical analysis of a set of newly-identified drafts of the text.

One of Prof Du Toit’s most substantive inquiries, though, was into the question: Was the amnesty provision of the Postamble the product of an underlying amnesty ‘pact’ between the NP government and the ANC?


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