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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Young researcher from UFS on SAYAS executive committee
2014-10-28



Dr Aliza le Roux
Photo: Sonia Small
Dr Aliza le Roux from the Department of Zoology and Entomology on the UFS’s Qwaqwa Campus is one of ten young scientists who was recently inaugurated as a new member of the South African Young Academy of Science (SAYAS). Not only was she inducted into the society this past October, but she was also elected to serve on the executive committee for SAYAS.

Dr Le Roux’s research focus is on cognitive ecology, behavioural ecology and zoology. She has expressed her excitement about the new position, and is already developing new ideas with her new colleagues on drawing more young people into the South African scientific community.

This position provides a regional and international platform to raise the profile of science in general, and Le Roux hopes to be active in SAYAS’s new mentorship collaboration with the New York Academy of Sciences, and to introduce new methods of scientific outreach using social media. Inspired by the students on the Qwaqwa Campus, Dr Le Roux hopes to specifically target relatively isolated rural campuses in SAYAS’s activities.

Prof Corli Witthuhn, Vice-Rector: Research at the UFS, said, “Aliza le Roux is an outstanding young scientist on our Qwaqwa Campus. I am very excited about the young researchers on our Qwaqwa Campus with Aliza as one of the leaders, and I am looking forward to what else they can achieve in the next five years.”

SAYAS was launched in October 2011 with 20 founding members as a mechanism to propel South Africa’s young scientists to fully participate in relevant local and international research and development agendas. It provides a national platform where leading young scholars from all disciplines in the country can interact, and also access international networking and career development opportunities.

SAYAS contributes primarily to the achievement of the national strategic priority of strengthening the skills and human-resource base of the country. Its particular niche is to focus on strengthening high-level skills among young scientists and the promotion of scientific excellence.


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