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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Prof Finkelstein current and only A-rated researcher in Probability and Statistics in SA
2014-10-28



Prof Maxim Finkelstein
Photo: Johan Roux
Prof Maxim Finkelstein from the Department of Mathematical Statistics at the University of the Free State (UFS) received an A-rating from the National Research Foundation (NRF). This makes him the only A-rated researcher in ‘Probability and Statistics’ regarding Mathematical Sciences in the country.

According to the NRF-rating process, a person with an A-rating is a world leader in his field. 

Prof Jonathan Jansen, Vice-Chancellor and Rector, said: "I am absolutely delighted for Professor Finkelstein and for the fact that this is one of the clearest signs that the UFS has significantly increased its standards of research across the institution as a whole."

Prof Finkelstein says this rating means a great deal to him, since it is a reflection of his dedication and perseverance.

“Of course, the rating is not a goal in itself,” Prof Finkelstein says. “The goal is the high quality research and the rating is just an objective indication of this. Along with the satisfaction, this rating brings the responsibility for maintaining this high status in the future.”

Prof Finkelstein conducts his general research in the field of ‘Probability and Statistics’, but his specific area of focus is ‘Stochastic Modelling’. Prof Finkelstein solely lectures postgraduate students and also mentors a few master’s and PhD students. This affords him the time to mainly concentrate on his research.

“Finally, I wish to emphasise the fact that high-quality research became the prime goal at the UFS,” says Prof Finkelstein. He underscores the efforts of the Vice-Chancellor and the Vice-Rector: Research in creating excellent possibilities for researchers. This has already resulted in remarkable improvements in the UFS’s research outputs – and consequently an increase in the number of rated researchers at the university.

A total of 119 UFS researchers currently have evaluation and rating status from the NRF, says Nico Benson, Deputy Director: Research Development. Currently (October 2014) 29 researchers are still waiting for response from the NRF regarding applications submitted. A total of 16 ratings are already known. On the Qwaqwa Campus of the UFS, five researchers are rated.

Prof Finkelstein's A-rating will become effective from 1 January 2015. Ratings are valid for a period of six years and researchers are invited to apply for re-evaluation in the fifth year.


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