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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Department of Chemistry receives accolades at international conferences
2014-11-11

 

From the left are: Prof Andreas Roodt, Renier Koen, Dr Marija Zbacnik and Prof Deon Visser.
Photo: Supplied

Staff members in the Department of Chemistry at the University of the Free State (UFS) excelled at recent international conferences. Prof Andreas Roodt, Head of the Department of Chemistry, was honoured at the Pan African Meeting of the International Year of Crystallography IYCr2014. This event was hosted on our Bloemfontein Campus and delegates from 22 countries delivered their papers at the congress.

Prof Roodt received a medal from the President of the Moroccan Crystallographic Association, Prof Abdelmalek Thalal, for 'Building Science in Africa through Crystallography as President of the European Crystallographic Association'. Prof Deon Visser gave a keynote lecture at this meeting, while Dr Marija Zbacnik, post-doctoral fellow in Chemistry, received a prize for the best poster presentation.

Similarly, Chemistry PhD student, Renier Koen, received the prize as best student speaker at the Light Metals AMI (Advanced Metal Initiative) conference held at Kwa Maritane in Pilanesberg. Plenary speakers included delegates from the United Kingdom, the United States, India, China and South Africa.

Profs Roodt and Visser received a special scroll for having produced the best student speakers at the AMI series of conferences for the past three years in a row. The previous best student lectures were presented by Maryke Steyn (2012) and Tinus Viljoen (2013).

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