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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Traditional medicine can play important role in modern drugs discovery
2014-11-11

Indigenous knowledge possesses a great potential to improve science. Making use of this source may lead to advanced technological innovations. This is according to Dr Sechaba Bareetseng, UFS alumnus and Indigenous Knowledge Systems (IKS) Manager at the Council for Scientific and Industrial Research (CSIR).
Dr Bareetseng recently addressed the seventh annual IKS symposium on the Qwaqwa Campus.
“Interfacing indigenous and local knowledge with scientific knowledge has the potential of encouraging and developing inventions, especially in the pharmaceutical industry,” said Dr Bareetseng.
 
“Such interfacing can also enable access to both sets of knowledge without any discrimination whatsoever. It would also encourage co-existence that would improve understanding between the two.”
 
“Traditional medicine,” said Dr Bareetseng, “can play an extended role in modern drugs discovery as it is already happening in Botswana and New Zealand. These two countries are leading this wave of new thinking in as far as drug development is concerned.”
 
Dr Bareetseng also called on established researchers to start embracing the local communities into their research.
 
“Contemporary scientific research demands that local communities must co-author research conducted within and with them by the universities and research institutions. This would help in maintaining trust between the researchers and the communities that feel exploited. Regular feedback would also make communities feel part of the developments,” Dr Bareetseng argued.
 
He further called on the pharmaceutical companies specifically and researchers in general to convert valuable indigenous knowledge and resources into products and services of commercial value. “Plants, the ecosystem and indigenous knowledge must be preserved to provide a source of income for the local communities. Communities must also be protected from foreign exploitation of their intellectual property.”
 

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