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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

"Studies indicate disability, poverty and inaccessibility to healthcare are intricately linked " - expert opinion by Dr Magteld Smith
2014-12-03

Dr Magteld Smith

Programmes worldwide attempt to improve the lives of people with disabilities, but recent studies indicated that disability and poverty, as well as disability and the inaccessibility of health care, continues to go hand in hand.

In South Africa, and even in developed countries, research shows that people with disabilities achieve lower levels of education with higher unemployment rates, live in extreme poverty and have low living standards.

“To have a disability can therefore become a huge financial burden on either the disabled person, the family or caregivers,” says Dr Magteld Smith from the Department of Otorhinolaryngology.

She devotes her research to the medical-social model of the global organisation, the International Classification of Functioning, Disabilities and Health, focusing on all areas of deafness.

Furthermore, Dr Smith says it is more difficult or more expensive for people with disabilities to obtain insurance, because of the risks associated with disability.

Dr Smith also emphasises the inaccessibility and even unavailability of medical services or health care for people with disabilities.

“Services such as psychiatry or social services are often not accessible. When such services are available, it is not affordable for most people with disabilities.”

Dr Smith uses the example of a person who was born deaf:

“Doctors have limited knowledge of the different types of hearing impairments or how to read and interpret an audiogram. Very little understanding also exists for the impact of deafness on the person’s daily life.”

Dr Smith, who is deaf herself, describes the emotional state of mind of people with disabilities as a daily process of adjustment and self-evaluation.

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