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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS implements paperless meeting system
2004-08-20

 

The Management Committee of the University of the Free State ’s (UFS) Executive Management recently entered the electronic environment of more effective and centralised meeting and decision-making administration by implementing ‘n computerised meeting system.

With this the UFS became the first higher education institution in the world to use the PARNASSUS-meeting management system. PARNASSUS , which refers to a mountain in the Greek mythology, is a licensed system from CIPAL in Belguim – a developer of software for a variety of applications.

“In stead of coming to a weekly management meeting with a file of documentation, each member now walks in with his/her laptop and the whole meeting procedure takes place electronically,” says Prof Sakkie Steyn, Registrar: General at the UFS.

At the same time the secretary registers the minutes point by point on the PARNASSUS programme. At the end of the meeting, after certain technical finishes are done, the minutes are distributed to members of the meeting and their secretaries/office managers. The draft minutes is also distributed to those who must implement decisions and prepare implementation steps. These staff members are given security clearance beforehand.

“The system is unique due to the fact that a translation engine has been built into the agenda and minute system. Agenda items can be submitted in Afrikaans and then automatically be translated in English by means of the interactive translation engine, or vice versa. The same principle applies to the minutes,” says Prof Steyn.

According to Prof Steyn the translation engine was develop with the expert assistance of the UFS’s Unit for Language Facilitation and Empowerment (ULFE). Word strings from previous minutes are now being added to the corpus of the translation engine.

“The system enables the secretary to continuously monitor which points are submitted for the agenda and if these points comply with the set standards namely clear recommendations, background and proposed implementation steps. The agenda is closed at a certain moment and no new points can then be added. The secretary does certain technical finished by means of a final classification of point and annexures. The draft agenda is then sent to the chairperson for approval, after which the agenda is electronically sent to members of the meeting and their secretaries/office managers for preparation,” says Prof Steyn.

“After the minutes have been approved at the next meeting, it is saved on the PARNASSUS decisions data base. The tracing of decisions made during previous meetings can be done by any person with the necessary security clearance. This is different from the past where stacks of documents had to be searched to find a decision,” says Prof Steyn.

According to Prof Steyn the secretariat and meeting administration services at the UFS has now entered a fully virtual and electronic environment. This will enhance effective decision making tremendously. “The PARNASSUS system saves us costs and time and the decentralisation of submissions to meetings lessens the work at centralised points,” says Prof Steyn.

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