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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Six from Physics receive doctorates at UFS Winter Graduation
2015-07-08

From the left are: Prof Koos Terblans, Dr Shaun Cronje, Dr Hendrik van Heerden, Dr Pieter Barnard and Prof Pieter Meintjes.
Photo: Stephen Collett

The Department of Physics at the University of the Free State (UFS) is extremely proud of six graduands who received doctorates at this year’s Winter Graduation which took place from on the Bloemfontein Campus from 1-2 July 2015. Three of the graduands are personnel in this department.

According to Prof Koos Terblans from the Department of Physics, it seems to be the most PhDs awarded at the university during one graduation ceremony.

The following people received doctorates:
1) Dr Shaun Cronje (UFS)
He investigated the loss of surface atoms during segregation of Sb from Cu using a computational model and experimental measurements.

2) Dr George Tshabalala (UFS)
He synthesised and characterised down-conversion nanophosphors.

3) Dr Hendrik van Heerden (UFS)
He searched for pulsed high-energy non-thermal emission from the nova-like variable system AE Aquarii.

4) Dr Pieter Barnard (SASOL)
He investigated the surface segregation of S in Fe and Fe-Cr alloys using computational models and experimental methods.
5) Dr Luyanda Noto
He investigated the luminescence mechanisms of tantalite phosphors.

6) Dr Alida Odendaal (UFS)
She investigated the multi-wavelength properties of a sample of Magellanic cloud and Galactic supersoft X-ray Binaries.

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