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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UN-recognised scholar awarded the prestigious TRI Annual PhD Award
2015-11-09

Dr Anneli Botha, winner of TRI Award for Best Doctoral Thesis.
Photo: Supplied

Two years after enrolling as a PhD candidate in the University of the Free State’s (UFS) Department of Political Studies and Governance, Dr Anneli Botha was awarded the annual Terrorism Research Initiative (TRI) Award for the 'Best Doctoral Thesis on Terrorism and Counter-Terrorism' (2014).

The TRI PhD award is a prestigious international honour, while terrorism as a scholarly venture remains a concentrated field. Dr Botha, one of the few women in this niche field, has proved to be an excellent asset. Her winning of the prestigious award was announced in its October 2015 issue of Perspectives on Terrorism (PT), a globally-circulated online journal, co-published by the European-based Terrorism Research Initiative and the America-based Center for Terrorism and Security Studies.

Based on the merit and relevance of her outstanding research, the United Nations Development Programme has appointed Dr Botha as a Consultant on Radicalisation. In addition, her PhD is to be published as a book in the United States of America early in 2016. She was appointed as a Research Associate at the University of the Free State at the beginning of this year.

An award-winning search for answers

Her thesis, titled “Radicalisation to Terrorism in Kenya and Uganda: a Political Socialisation Perspective”, tackled East African militancy, from an individualised perspective. Researchers in the past have neglected assessing details of the rebels’ childhoods. Dr Botha’s interviewed about 285 militants and their families. These individuals declared themselves openly as members of al-Shabaab and the Mombasa Republican Council (MRC) in Kenya, and the Allied Democratic Forces (ADF) and the Lord’s Resistance Army (LRA) in Uganda, at the time of the interviews.

Her doctoral dissertation provides significant information about factors that should be considered in the quest to counter and prevent terrorism. Her research shows conclusively that political socialisation begins with the family, and expands through peers, school, media, and earlier political experiences, culminating in the terrorist group.

Outstanding piece of scholarship

Dr Alex Schmid
, who is the editor of PT, TRI Award Jury chairman, and one of the most respected experts of terrorism, described Dr Botha’s research as an “outstanding piece of scholarship.”

Dr Botha attributed her success to her supervisors - Professors Theo Neethling and Hussein Solomon - as well as to the people in Kenya and Uganda.

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