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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Linguistic resourcefulness impresses at 15th Student Symposium on the Natural Sciences
2015-11-26


UFS students walk away with more than half the prizes at this year’s Student Symposium on the Natural Sciences.

This year, the fifteenth annual Student Symposium on the Natural Sciences was hosted on the Bloemfontein Campus by the UFS Departments of Chemistry and Physics, together with the South African Academy for Science and Arts (SAAWK).

According to Dr Ernie Langner, Senior Lecturer in the Department of Chemistry, this symposium provides postgraduate students from all over South Africa the opportunity to present their research in Afrikaans, to learn from each other, receive feedback on their work through the review process, and to build networks. If their abstracts are selected for publication in the Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie, it also provides them with further exposure in the broader academic context.

Besides research of the highest quality, this year's symposium had no shortage of linguistic resourcefulness. “Students, accustomed to writing and expressing their research in English, astonished everybody with their beautiful Afrikaans. Outstanding research from honours, master's, and doctoral students was expressed in scientific terminology of the highest standard,” Dr Langner said.

The Student Symposium is the only event (worldwide) where the development of 'elektrostatiese potensiaalkaarte', 'femtosekonde pomp-proef spektroskopie', or 'endokrien-ontwrigtende chemikalieë' is explained step by step. This is where one hears enthusiastic students talking about how hard they are working on 'geïntegreerde drywende sonkragstelsels', or 'geneste virtuele rekenaars binne die wolkstelsel'. The results of hours of hard work in the lab, cold nights behind a telescope, or long midnight sessions in front of the computer, had to be condensed into 15-minute presentations on the synthesis of metal-organic networks, or metal-carbene complexes, the identification of pulsar rhythms, or the refining of rapid-eye technology.

Of approximately forty participants from five universities, eighteen were awarded prizes for their papers and posters. Students from the UFS walked away with more than half of the awards. Jacques Maritz (Physics) and his wife, Elizabeth, (Mathematics and Applied Mathematics) from the UFS were both awarded first place in their respective sessions.

 

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