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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

SARChI Chair on disease resistance and quality in field crops awarded in UFS Department of Plant Science
2016-02-01

Description: SARChI Chair  Tags: SARChI Chair

Prof Labuschagne

A South African Research Chairs Initiative (SARChI) chair has been awarded in the Department of Plant Sciences at the University of the Free State (UFS). The chair will be headed by Prof Maryke Labuschagne, and will focus on crop quality breeding and disease resistance in field crops.

The disease resistance research by the chair will be headed by Prof Zakkie Pretorius. The disease resistance breeding will be a continuation of the internationally-acclaimed wheat rust research that Prof Pretorius has been conducting during his career.

The quality breeding will focus on crop protein quantity and quality as well as on iron, zinc, and beta carotene biofortification of staple crops such as wheat, maize, and cassava.

Prof Labuschagne believes that food security is one of the key factors for stability and prosperity on the continent. Her research and that of her students focuses on the genetic improvement of food security crops in Africa, including such staples as maize and cassava. “These crops are genetically improved for yield, drought tolerance, disease, and insect resistance, as well nutritional value,” she said.

Last year, one of  Prof Labuschagne’s PhD students, Bright Peprah, received an award for $473 000 from the competitive Program for Emerging Agricultural Research Leaders (PEARL) of the Bill and Melinda Gates Foundation for his project on improving the beta-carotene content in cassava.

Prof Labuschagne also received the prestigious ‘Continental Lifetime Achiever Award’ from Africa’s Most Influential Women in Business and Government Programme (MIW) last year for her commitment and continuous contributions to food security. She is an NRF-rated researcher, and author or co-author of over 160 articles in accredited journals.

Research Chairs have been designed by the Department of Science and Technology, together with the National Research Foundation, to attract and retain excellence in research and innovation at South African public universities. 

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