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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Female-headed households more prone to economic strains due to rainfall variations
2016-02-02

Description: Martin Flatø  Tags: Martin Flatø

Martin Flatø
Photo: University of Oslo press

Research shows that a total of 41 % of South African (SA) households are led by women, and these households are twice as likely to be poor compared to other households.

Martin Flatø spent three months at University of the Free State (UFS), researching how female-headed households in our country are affected by variations in rainfall, which cause crop failures with their implications for rural economies.

He is a PhD student from the University of Oslo in Norway who was part of the 2014/15 Southern African Young Scientists Summer Programme (SA-YSSP) that was hosted by the UFS last year.

Flatø formed part of a group of international scholars who conducted research on how families led by females are affected by climate change. The group focused on the implications of the weather on crop failures and rural economies. Gender and household structures were studied to determine ways in which they are affected by economic fluctuations.
 
The research group’s preliminary findings indicate that female-headed households are more vulnerable to rainfall variation than households where there are adult residents or workers of both genders.

In view of the current water shortage in the Free State, as well as scientists’ projections that our country will be among the regions hardest hit by climate change in terms of a surge in temperature, Flatø’s collaborative research has substantial relevance.|

Grooming first class scientists
The SA-YSSP is a joint initiative of South African National Research Foundation and the International Institute of Applied Systems Analysis (IIASA). Its main aim is tackling challenges faced by the world at large and South Africa in particular.

Out of 24 PhD students from 18 countries and various academic disciplines, Flatø emerged as one of only three scholars to be awarded the Systems Analysis Scholarships for his outstanding science at the end of the programme.

World class mentorship
Prof André Pelser and Dr Raya Muttarak were Flatø’s SA-YSSP supervisors. Prof Pelser, of the UFS Department of Sociology, is a leading academic on population processes, and how they relate to local environmental issues in South Africa. Dr Muttarak is a research scholar at IIASA in Austria.

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