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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Seasoned international pianist appointed at the OSM
2016-02-05

Description: Dr Grethe Nöthling Tags: Dr Grethe Nöthling

Dr Grethe Nöthling

The Odeion School of Music is delighted to welcome Dr Grethe Nöthling as a new member of its dynamic performance faculty.

Dr Nöthling has been appointed as principal piano lecturer. She has won several national music competitions, and is the recipient of numerous awards and bursaries, including the University of South Africa overseas scholarship for teachers in 2003.

Musician and pedagogue par excellence

From 1989 to 2005, Dr Nöthling performed as soloist with all major South African Symphony Orchestras. She obtained a Bachelor of Music Degree (magna summa cum laude), specialising in Performance from the University of Pretoria under the tutelage of Professors Ella Fourie and Joseph Stanford.

She furthered her studies in the United States of America at the Cleveland Institute of Music where she received a Master’s of Music Degree in 2008 under the guidance of Daniel Shapiro and Paul Schenly.

Dr Nöthling obtained a Doctorate of Musical Arts Degree (2014) from the University of Iowa (UI) in the USA under Professor Uriel Tsachor. During her studies at the U of I, she was awarded a teaching assistantship, and performed with the university’s New Music Ensemble. During a ten-year residency in the USA, she has performed extensively as both soloist and chamber musician.

Inspiration for aspiring musicians

“It is my hope to be an inspiration for young and upcoming musicians both as pedagogue and performing artist. In order to consider the unique gifts and challenges of every individual student, I am of the opinion that is imperative to be very flexible and adjustable from a methodological and musical perspective,” said Dr Nöthling.

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