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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Science and goodwill meet drought-stricken communities
2016-03-02

Description: Disinfecting tankered water  Tags: Disinfecting water

“Everyone should contribute to the delivery of clean water to every individual,” says UFS researcher.

The drought in South Africa has impacted the country in many ways. Apart from its economic and environmental implications, the drought also has social implications, leaving some communities without water.

Since 21 January 2016, the Department of Water and Sanitation (DWS) is working together with the Department of Microbial, Biochemical, and Food Biotechnology at the University of the Free State. Dr Mariana Erasmus, post-doctoral fellow in the department, was appointed to lead a project for disinfecting tankered water supplied by the DWS to communities without water in the Qwaqwa area - which falls under the Maluti-a-Phufung Local Municipality.

She is working on the project with Robbie Erasmus from BioSense Solutions and Martin Bambo from DWS. A total of 53 trucks, 91 tanks, and 420 500 litres of water was disinfected so far, using sodium hypochlorite. “This is standard practice around the world,” Dr Erasmus said.

The work done by the UFS and DWS, who is monitoring the water quality as well as the process of water delivery, is very important. Disinfecting the trucks used to deliver water to drought-stricken communities decreases the formation of biofilm inside the tanks. “The biofilm could contain harmful bacteria such as E-coli. It is important to note that this is mostly the result of secondary pollution, since the water quality from the source where it was taken from, proved to be good. Drinking water with this harmful bacteria that has not been properly managed, can lead to health issues in humans when consumed,” Dr Erasmus said.

The Department of Microbial, Biochemical, and Food Biotechnology, interacting with the DWS on several water-related issues, volunteered to get involved in the project. They strongly believe that everyone should contribute to the delivery of clean water to every individual.

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