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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Mafuma aims at elusive tournament victory with Junior Springboks
2016-06-03

Description: Mafuma Tags: Mafuma

The University of the Free State’s Mosolwa Mafuma
recently scored five tries in the Junior Springboks’
three practice matches against a Golden Lions U20
invitation team, a Maties team, and the
South Western Districts. Photo: SASPA

He has never won a rugby tournament, so Mosolwa Mafuma has only one goal: to win the Junior World Cup as Junior Springbok in England.

Even though the 20-year-old Shimlas wing has achieved success, and it is pleasing to excel individually, he believes it is more satisfying when his team triumphs. According to Mafuma, who could just as well be an athletics star, he wants to help the South African U20 team take a different approach.

He and the prop Kwenzo Blose are players from the University of the Free State who will represent the Junior Springboks from 7 to 25 June 2016 in Manchester. The team will play the first of three group matches on 7 June 2016 against Japan in the Academy Stadium.

New approach for SA U20 team
Mafuma, who was Player of the Tournament in his first Varsity Cup in 2016, says the Junior Springboks are well prepared. “We have the skills, and the structures at the Junior Springboks are different than before. There is not just one game plan like playing with big guys. We want to try new things and have a different approach.”

It is with this team that he wishes to achieve something. “It is one thing to be able to say that you are the Player of a Tournament, but your team did not win. I have not won something at school (with St. Benedict’s Boys College in Johannesburg) or this year with the Shimlas.”

Speedster on athletics track
The speedster is one of only a few rugby players who also have a profile on the IAAF website. His fastest time in the 100 m is 10.37 seconds (a national U17 record) and 20.37 s in the 200 m.

In high school, this first-year Psychology student played rugby during winter and took part in athletics during summer. Only at the end of Grade 11 did he started focusing on rugby. “I was more of an athlete than a rugby player,” he says.

It is no coincidence that the nickname he acquired due to his speed, is Dash. His other nickname, Senkie (derived from the Afrikaans word ‘seuntjie’) he received as a child from his parents because he was such a small child.

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