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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Louzanne Coetzee heading for Paralympic Games in Rio
2016-08-02

Description: Louzanne Coetzee  Tags: Louzanne Coetzee

Louzanne Coetzee (left) from the University of the
Free State and her guide Khothatso Mokone, a former Kovsie,
will compete in the Paralympic Games in Rio de Janeiro,
Brazil, from 7 to 18 September 2016.
Photo: Rufus Botha

Her perseverance and faith. Faith in herself and her coaches, as well as her Christian faith. Rufus Botha says this is what makes the Paralympic athlete Louzanne Coetzee special. According to her coach, the 23-year-old star from the University of the Free State (UFS) is easy to work with. “Her work ethic is incredible. As coach, I actually have to stop her,” he jokes. “She does not like to rest.”

On 19 July 2016, Coetzee was included in South Africa’s Paralympic team for the Olympics in Rio de Janeiro, Brazil. She and her guide Khothatso Mokone, also a former Kovsie, were included in the team that will participate in Rio from 7 to 18 September 2016.

Sights still set on 2020 Olympics

In Brazil, Coetzee will compete in the T11 category in the 1 500 m. The blind athlete is also outstanding in the 800 m and 5 000 m, of which she is the world record holder, but these items do not feature at the Olympics.

Botha says Coetzee has her sights still set on the 2020 Paralympic Games in Tokyo, Japan. “Anything she achieves in Rio will actually be a bonus.” He says it was an achievement on its own to be included in the SA team among established athletes such as Arnu Fourie and Ilse (Hayes) Carstens.

CUADS super proud of record-breaker

“Anything she achieves in Rio
will actually be a bonus.”


“Louzanne is an absolute star and an example to so many Kovsie students,” says Martie Miranda, Head of the Centre for Universal Access and Disability Support (CUADS) at the UFS. “We are super proud of her.”

On 17 July 2016, Coetzee set a new Africa record (5:00:25) in the 1 500 m in Berlin. She will leave for Rio on 30 August 2016, with her heat taking place on 15 September 2016 and the finals on 17 September 2016.

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