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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

One, two, three – is your thesis done?
2016-08-26

Description: three-minute-thesis  Tags: three-minute-thesis

Winners of the UFS Three-Minute-Thesis competition.
From the left: Thutukile Jita, Natural/Social Sciences
PhD winner; Saheed Sabiu, Natural/Health Sciences
and audience-favourite PhD winner;
Matseliso Mkotywa, master’s audience-favourite
winner; Zingisile Mbo, Natural/Health Sciences
master’s winner.
Photo: Charl Devenish

“Next time you have three minutes to spare, try to formulate your master’s or doctoral thesis,” says Dr Henriëtte van den Berg, Director of the Postgraduate School at the University of the Free State (UFS).

The much anticipated Three-Minute-Thesis (3MT) Competition took place at the UFS Bloemfontein Campus on Friday 19 August 2016. Diverse and interesting research projects were discussed, giving one a glimpse into months and even years of hard work and dedication.

A learning opportunity for candidates
The 3MT competition is an international event founded at the University of Queensland, Australia. It is divided into master’s and PhD categories.  At the UFS competition, the master’s section was dominated by the Medical and Natural Sciences, in contrast with the PhD section’s focus on Social Sciences. “The competition is a learning opportunity for our UFS candidates,” says Dr Henriëtte van den Berg.

Thought-provoking research presented
Interesting methodologies and research questions sustained the academic excellence the candidates pride themselves in. Saheed Sabiu, PhD candidate and winner, constructed his thesis around, Waste to Health: Corn silk in the Management of Kidney Diseases. “Use corn silk (white fibre around corn) in the same manner as a tea bag, to help manage kidney diseases,” says Sabiu.

Audience members also had the opportunity to ask the candidates questions relating to their thesis topic.

Winners at the event:
•    Master’s winner: Zingisile Mbo
•    PhD winner: Natural/ Health Science: Saheed Sabiu
•    PhD winner: Natural/Social Sciences: Thutukile Jita

The winners of each category received a cash prize and will represent the UFS at the national 3MT competition, hosted by the UFS in November this year.

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