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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

PSP rejuvenating the South African professoriate
2016-10-25

Description: Dr Olihile Sebolai  Tags: Dr Olihile Sebolai

Dr Olihile Sebolai (Microbiology) is
one of two Fulbright scholars the
UFS Prestige Scholars’ Programme
has produced. He was a Fulbright
scholar at the University of Missouri
(Kansas City) and before that
conducted work at the University
of Birmingham in the UK.
Photo: Anja Aucamp

Twenty years. That is the difference between the average age of a UFS Prestige Scholar (35) and the average age of a South African academic (55). Since its inception in 2011, the UFS’s Prestige Scholars’ Programme (PSP) has pro-actively addressed the ageing profile of academia and the need to transform the social composition of the South African academy. In doing so it has generated more than R67 million in research funding, including R10 million in student and post-doctoral funding.

The programme seeks to identify, cultivate and promote outstanding scholarship among “young” members of the UFS academic staff – those who have acquired a doctorate within the last five years. It provides support (funding applications, report writing, etc.) and helps with international placements in order to accelerate the establishment of an international footprint in expectation of the participants’ entry into the professoriate.

The programme mentors scholars from five faculties at the UFS. PSP scholars have conducted research and established collaborations in North America, Europe and Japan at institutions such as Harvard, UCLA, Cornell University, University of Michigan, University of Missouri, University of British Columbia, Oxford University, Cambridge University, University of Manchester, University of Birmingham, Basel University, University of Bologna, Leiden University, Uppsala University, Okinawa Institute of Science & Technology and Obihiro University of Agriculture and Veterinary Medicine.

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