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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Care centre goes high-tech to help sexual abuse victims
2016-11-25

Description: Colposcope Tags: Colposcope

The colposcope, donated by the Discovery Fund,
will be used during gynaecological examinations
to detect any irregularities.
Photo: Supplied

Rape is one of South Africa’s most pressing social problems. Rape levels in the country are often discussed and reported on, but it does not deter perpetrators from this behaviour. According to Africa Check, of the more than 42 000 rape cases reported in 2015, 15 790 were child rape cases.

In an effort to assist victims of sexual assault and rape, the University of the Free State (UFS) Department of Family Medicine adopted the Tshepong Thuthuzela Care Centre, under the leadership of UFS lecturer Dr Mariaan Kotze.

The Discovery Fund donated a colposcope to Tshepong Thuthuzela Care Centre, an instrument that works with the help of a bright light and which is used to examine victims of abuse. It has also become a standard of good practice in the assessment of child abuse worldwide. According to Dr Kotze, the new instrument will also be used for training health practitioners by rendering clinical forensic services to abuse victims.

Managing complex issues

The care centre works with between 80 and 120 victims of rape each month, a third of whom are children under 14 years of age. According to Dr Kotze, the management of child sexual abuse victims is more complex than with adults; as there is a higher chance of missing or over-diagnosing abnormalities. Also, she says, the examination process is often observed by a group of healthcare practitioners, an experience which is often intrusive and intimidating for the child. With the colposcope, the timeframe of the examination is shortened, and can be captured and viewed in real time, without the victim being present.

Best care for victims

The colposcope is a magnifier and light source used during gynaecological examinations. It is instrumental in providing the best care to victims of sexual abuse, and helps diagnose and assist in the treatment of cases of abuse. Its ability to capture and review images at the time of examination allows for retrospective research, and improves the ability of expert witnesses in court cases.

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