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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Young researchers shine during Afromontane Colloquium
2016-12-01

Description: Afromontane Colloquium  Tags: Afromontane Colloquium  

From the left are Drs Reetu Sogani (India),
Greg Greenwood (US-Switzerland), Teboho Manchu
(Acting Campus Principal), Drs Jianchu Xu (China),
Henri Rueff (Switzerland), Glen Taylor (Senior Director:
Research Development), and Elsa Crause
(Campus Vice-Principal: Academic and Research).

The University of the Free State’s Afromontane Research Unit (ARU), which is situated on the Qwaqwa Campus, has the potential to produce some of the world’s best and dynamic young researchers. This is the view of Dr Henri Rueff, who was one of the keynote speakers during the recent ARU Colloquium hosted at Golden Gate in the Eastern Free State.

Dr Rueff, a geographer and environmental economist from the Universities of Basel and Bern in Switzerland, was referring to no less than ten Qwaqwa Campus postgraduate students who made oral and poster presentations during the inaugural international colloquium.

“You have some of the world’s most motivated and highly skilled students who have the courage to stand in front of extremely critical scientists from all over the globe – and that must be commended,” he said.

Also talking about the students at the colloquium, was Dr Reetu Sogani from India, who said that her first trip to South Africa did not disappoint. “This colloquium was a very good learning experience for me as I had the opportunity to interact with brilliant and young scientists from this part of the world,” she added. In closing the colloquium, the Senior Director: Research Development, Dr Glen Taylor, committed the UFS to the success of the unit.

“The ARU will strengthen the research output of the campus. But most critically, it is setting the research agenda for the Qwaqwa Campus, and for the institution at large, to address the challenges that the surrounding mountain communities are faced with,” he said.

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