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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS study shows playing time in Super Rugby matches decreasing
2016-12-19

Description: Super Rugby playing time Tags: Super Rugby playing time 

The study by Riaan Schoeman, (left), Prof Robert Schall,
and Prof Derik Coetzee from the University of the Free State
on variables in Super Rugby can provide coaches with
insight on how to approach the game.
Photo: Anja Aucamp

It is better for Super Rugby teams not to have the ball, which also leads to reduced overall playing time in matches.

This observation is from a study by the University of the Free State on the difference between winning and losing teams. Statistics between 2011 and 2015 show that Super Rugby winning teams kick more and their defence is better.

These statistics were applied by Riaan Schoeman, lecturer in Exercise and Sport Sciences, Prof Derik Coetzee, Head of Department: Exercise and Sport Sciences, and Prof Robert Schall, Department of Mathematics and Actuarial Sciences. The purpose of the study, Changes in match variables for winning and losing teams in Super Rugby from 2011 to 2015, was to observe changes. Data on 30 games (four from each team) per season, supplied by the Cheetahs via Verusco TryMaker Pro, were used.

About two minutes less action
“We found that the playing time has decreased. This is the time the ball is in play during 80 minutes,” says Schoeman. In 2011, the average playing time was 34.12 minutes and in 2015 it was 31.95.

“The winning team has less possession of the ball and doesn’t want it. They play more conservatively. They dominate with kicks and then they play,” says Prof Coetzee, who was the conditioning coach for the Springboks in 2007 when they won the World Cup.

Lineouts also more about kicking
As a result, the number of line-outs also increased (from 0.31 per minute in 2011 to 0.34 in 2015) and the winning teams are better in this regard.

“The winning team has less possession of the ball
and doesn’t want it. They play a more conservative
game. They dominate with kicks and then they play.”

Schoeman believes that rule changes could also have contributed to reduced playing time, since something like scrum work nowadays causes more problems. “When a scrum falls, the time thereafter is not playing time.”

According to Prof Coetzee, rucks and mauls have also increased, (rucks from 2.08 per minute in 2011 to 2.16 in 2015 and mauls from 0.07 per minute in 2011 to 0.10 in 2015). “The teams that win, dominate these areas,” he says.

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