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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

PSP allows Dr Thom Wium to develop as an academic
2016-12-26

Description: Matildie PSP Tags: Matildie PSP 

For Dr Matildie Thom Wium, the
rewarding part of teaching is “the
moments of synergy with a group of
students” and when she senses that she
could, for instance, help them to better
understand a music selection.
Photo: Sonia Small

Being part of the Vice-Chancellor’s Prestige Scholars Programme (PSP) has opened doors for Dr Matildie Thom Wium. She is able to better plan her research, and the overseas trips she has to undertake for this helps to develop her skills.

The senior lecturer in the Odeion School of Music (OSM) at the University of the Free State (UFS) says these are some of the advantages the PSP holds for her.

She attended two international conferences this year – in London in January, and in New York in August. Furthermore, she is working on musical analysis with Prof Timothy Jackson at the University of North Texas, US from 12 September 2016 to 31 December 2016. Prof Jackson is a research professor and was one of her PhD promoters.

Conferences contribute to her vision
“I think the PSP is a fantastic initiative,” says Dr Thom Wium, whose husband Daniël Wium is a lecturer in Astrophysics at the UFS. She says the reseach support from the PSP is amazing. “In addition, the writing retreats offered by the PSP help to set time aside during the busy semester to work on articles.”

“I think the PSP is a fantastic initiative.”

The conference in London was on operatic practice in the 19th century. In the US, Dr Thom Wium, who has been working at the UFS since 2007, also participated in a panel discussion on this topic. “It means a lot for my vision as an academic to participate in conferences where I have the opportunity to meet and exchange thoughts with the people whose work I read and cite.”

Involvement in SA equally important

However, she believes that it is equally important to stay involved locally. At the conference of the South African Society for Research in Music, which was hosted by the OSM from 25 to 27 August 2016, she presented a paper on composer Arnold van Wyk and performed a song cycle by him. She did research on Van Wyk for her PhD.

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