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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

National 3MT competition held at UFS
2017-03-29

Description: 3MT 2017 Tags: 3MT 2017

The two winners of the Three minute thesis
competition, Andrew Verrijdt (left) and
Kerryn Warren (right).
Photo: Charl Devenish


From Neanderthal hybrid children to eating corn silk as a way of managing kidney diseases, the National Three Minute Thesis competition (3MT) captivated the mind.

“We brought the competition to South Africa and hosted the local, regional, and national competitions for the past few years,” said Dr Emmie Smit, organiser of the event. It is an opportunity to raise the profile of postgraduate research and to develop a cross-disciplinary student community to effectively communicate research to a wide audience. The event was founded by the University of Queensland, Australia. The third national 3MT competition took place at the University of the Free State (UFS) on Friday 24 March 2017.

Three minutes and one slide
During the competition, participants had three minutes to explain their master’s or doctoral research and one static PowerPoint slide could be used. “It is very important that this slide works for you. There must be some way the information on the slide connects to what you present,” said Dr Henriette van den Berg, Director of the Postgraduate School at the UFS.
 
Winners grateful for opportunity
“It is an honour and a drive. It is very nice to have this sort of thumbs up,” said Kerryn Warren, winner of the Science category. Her research title was, What did a Human-Neanderthal Child Look Like? “I have been looking at the hybrids between different species and subspecies of mice in order to use them as a model to find out what human hybrids looked like.”

The presentation by Andrew Verrijdt, winner of the Humanities category, entitled Hiding in the Deep: Anonymous Websites for Paedophiles on the ‘Darknet’, gave a glimpse into the mysterious and dangerous realm of the dark web. “I am grateful for the opportunity. Primarily because I think it’s an important topic, and society will benefit by getting the word out there as it is a sensitive topic,” he said. The two winners, both from the University of the Cape Town, won R15 000 each.  A further R30 000 of prize money went to the four runners-up.

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