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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Young Shimla team reach Varsity Cup semi-final
2017-03-29

Description: Young Shimla team reach Varsity Cup semi-final Tags: Young Shimla team reach Varsity Cup semi-final

The Shimlas will be hoping that some of their stars,
like the brilliant flanker Phumzile Maqondwana, will be
on form in the 2017 Varsity Cup semi-final against
Tuks in Pretoria.
Photo: Johan Roux

The pressure in the Varsity Cup semi-final is on Tuks, which will be reason enough for Shimlas to play with freedom.

This is according to Jaco Swanepoel, Shimla assistant coach, on the big challenge awaiting his young rugby team in Pretoria on 3 April 2017. He says because Tuks are the favourites, it could be to the advantage of the visitors. Maties and the University of Johannesburg are playing in the other semi-final in Stellenbosch on the same day.

Tuks did Shimlas a favour
Tuks’ victory of 43-28 over the Pukke in Potchefstroom on 27 March 2017 helped the Shimlas, who had a bye, to end fourth on the log with 23 league points.
Shimlas had to make use of several new players this year, and few experts would have given them a chance of reaching the semi-finals. Swanepoel says although they are proud of this achievement, only a place among the top four was never their end-goal.
    
Good to be the underdog

The Shimlas lost their league match against Tuks in Bloemfontein with 19-65. This, as well as the fact that Tuks was at the top of the log with 34 league points, underlines the huge task ahead.
“The previous result (against Tuks) is encouragement for the players to show: We aren’t that much worse than Tuks,” says Swanepoel. “Perhaps it is good to be the underdog. We actually have no pressure on us and I hope the players feel the same way.”

Three teams in knockout matches
All three Varsity Cup teams from the University of the Free State (UFS) reached the knockout matches. Apart from Shimlas, the UFS Young Guns played against Tuks in a semi-final in Bloemfontein on 27 March 2017, but lost by 21-45. On 17 April 2017, Vishuis will meet the Puk’s Patria in the residence finals.

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