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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Prof. Dingie Janse van Rensburg promoted to Outstanding Professor
2007-11-19

The University of the Free State (UFS) is pleased to announce that Prof. Dingie Janse van Rensburg, Director of the Centre for Health Systems Research and Development has been promoted to Outstanding Professor.

In 1991 the Executive Committee of the Council introduced the category of Outstanding Professor to give recognition to a small group of outstanding academics. Not many academics at the UFS received this status since then.

Prof. Janse van Rensburg has been working at the UFS for 37 years and played a big role in establishing a culture of scientific publication among young and upcoming researchers.

Prof. Janse van Rensburg enjoys extensive national and international recognition as researcher and research manager. He delivered various national and international papers and is involved in a variety of international research projects – some of which were initiated by him. He succeeded in involving a variety of foreign researchers in long term research projects.

In 1993 he established an entrepreneurial research and development centre, which he has sustained for more than 13 years. The centre enjoys recognition nationally as well as internationally as well as credibility in the eyes of the international donor community, within government’s health sphere as well as in peer academic circles.

Prof. Janse van Rensburg has for several years been a grant holder of both the National Research Foundation and the Medical Research Council for research projects on Tuberculosis and HIV/Aids.

During his career at the UFS Prof. Janse van Rensburg received several merit awards and commendations from the UFS and other institutions. These include the Stals Prize in 1993 from the Suid-Afrikaanse Akademie vir Wetenskap en Kuns, a Council Medal from the UFS in 2003, the UFS Centenary Medal in 2004, an award from the Department of Health in 2004 for excellence and continued support of this department, a promotion to Senior Professor from the UFS in 2005 and the Free State Premier’s Excellence Award Gold category in 2006 for excellence in research and development.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
19 November 2007
 

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