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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Three UFS researchers attend cactus pear congress
2017-05-05

Description: Dr de Wit Cactus pear 2 Tags: Dr de Wit Cactus pear 2

Dr Maryna de Wit, one of the
UFS delegation team was appointed
coordinator for Agro-Processing
and Post-Harvest Technology during
the congress

Description: Dr du Toit Cactus Pear 2 Tags: Dr du Toit Cactus Pear 2

Dr Alba du Toit, also one of the members
of the UFS delegation during the
congress at the University of Chile
in Santiago, Chile.
Photos: Supplied





Dr Alba du Toit, a junior lecturer in Consumer Science at the University of the Free State (UFS), presented her research at the recent IX International Congress on Cactus Pear and Cochineal at the University of Chile in Santiago, Chile. The congress was themed, “CAM Crops for a Hotter and Drier World”.

Dr Du Toit, Prof HO de Waal and Dr Maryna de Wit, from the Faculty of Natural and Agricultural Sciences at UFS, attended the five-day conference held between 26 and 30 March 2017.

Congress a platform for networking
The congress, held every three years since 1993, gathers cactus pear researchers, growers and processing managers from Europe, the Americas, Asia and Africa to review current research trends by networking to form new collaborations that could lead to increased efficiency and shared knowledge. They also present new findings and plan for future research.

Great achievements for researchers
Dr Du Toit said: “My research on cactus pears focused on the utilisation of the slimy substance found in the cactus cladodes as a functional ingredient in innovative nutraceutical food products”. Functional foods are foods that promote health or prevent disease through adding or omitting specific ingredients. She also received the International Society of Horticultural Science award for best student oral presentation.

Dr De Wit also presented her research and was appointed coordinator for Agro-Processing and Post-Harvest Technology at the congress.

Dr Herman Fouché, Affiliated Researcher at the Department of Soil-, Crop- and Climate Sciences at UFS, developed “kuilmoes”, a type of silage from pulped cactus pear fruit, mixed with lucerne, in collaboration with Prof de Waal, which was also presented.at the congress.

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