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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Researchers celebrated for outstanding achievements
2017-05-05

Description: Researchers celebrated for outstanding achievements Tags: Researchers celebrated for outstanding achievements

From left, NRF P-rated researcher,
Dr Daniel Spence; Directorate Research
Development, Eleanor van der Westhuizen;
Vice-Chancellor and Rector Prof Francis Petersen;
Dean of Faculty of Theology Prof Fanie Snyman;
and Vice-Rector: Research, Prof Corli Witthuhn.
Photo: Johan Roux


The University of the Free State’s (UFS) Vice-Rector: Research, Prof Corli Witthuhn, hosted a Research Celebration, at which the new National Research Foundation (NRF) ratings, presentation of the UFS Book Prize and the research support award were announced. The UFS Chancellor, Dr Khotso Mokhele, and Chairperson of the UFS Council, Mr Willem Louw, were in attendance among academics and staff members. 

An astounding preface
Presenting the opening remarks, UFS Vice-Chancellor and Rector, Prof Francis Petersen, congratulated all researchers and prize recipients on behalf of the rectorate. He applauded all researchers who had put their best foot forward and were acknowledged by the NRF. Furthermore, Prof Petersen said that the success of UFS researchers informed that the university received international recognition. “Research has the ability to play an active role in transformative action that leads to change. We are striving to be a leader in research output,” said Prof Petersen.

Humble and gracious recipient
Prof Fanie Snyman, Dean of the Faculty of Theology, walked away with the most sought-after award of the day, the UFS Book Prize for Distinguished Scholarship, for his book, Malachi, on the last book of the Old Testament. The book was published in Germany and can be used by theology scholars and academics.

“I have no words, I am sincerely grateful for this award, but I must also thank the university. I am grateful for the support that has enabled me to complete the book and achieve this award,” said Prof Snyman. He is the third academic to be awarded this prize.

University reaches new heights
The university’s new NRF-ratings were celebrated. The UFS has 27 new rated researchers and seven researcher’s ratings were renewed. Prof Jonathan Jansen received a NRF A-rating and Dr Daniel Spence a P-rating.

The Directorate of Research Development’s Eleanor van der Westhuizen was awarded the Research Support Award, which is to acknowledge those who accelerate and propel research and/or researchers.

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