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19 July 2018 Photo Supplied
AEVGI advances Next-Generation Sequencing in Africa
Prof George Armah, Noguchi Memorial Institute for Medical Research, Ghana; Prof Carl Kirkwood, Bill and Melinda Gates Foundation, USA; Cornelius Hagenmeier, Director: Internationalisation, UFS; Prof Gert van Zyl, Dean: Health Sciences; Dr Martin Nyaga, Senior Lecturer in the NGS Unit; Prof Joyce Tsoka-Gwegweni, Vice-Dean: Health Sciences; Dr Glen Taylor, Senior Director: Research and Development; Prof Jeffrey Mphahlele, Vice-President, South African Medical Research Council.

The inaugural edition of the University of the Free State (UFS) Next-Generation Sequencing (NGS) Data and Bioinformatics Workshop, hosted by the UFS-NGS Unit in the UFS Faculty of Health Sciences, marked a new beginning for the advancement of NGS in Africa under the auspices of the African Enteric Viruses Genome Initiative (AEVGI), which was recently funded by the Bill and Melinda Gates Foundation.

The AEVGI will generate rotavirus genomes at the UFS-NGS Unit to investigate the long-term effects of the introduction of the monovalent RV1 vaccine in three African countries – Ghana, Malawi, and South Africa.

The workshop attracted over 90 participants from 15 national and international institutions, with organisations from seven different countries as well as company representatives attending the event. The workshop kicked off with a courtesy call to the Rector and Vice-Chancellor, Prof Francis Petersen, followed by a stakeholder meeting with the executive management of the UFS.

The funding was secured through an award to the principal investigator, Dr Martin Nyaga, and sub-awards to co-investigators, Dr Khuzwayo Jere, Dr Francis Dennis, and Dr Valentine Ndze. According to attendee evaluations of the workshop, the remarkable performance of the workshop instructors was outstanding. Through practical sessions, participants were equipped with knowledge on how to apply several tools of genetic data analysis, using the rotavirus genome as a model to construct and interpret different genomic datasets.

A total of 65 students attended the hands-on workshop, the majority of which were from South African higher-education institutions. The organisers are grateful to the sponsors, particularly to the Bill and Melinda Gates Foundation and the University of the Free State, for making the workshop a success. Whitehead Scientific and the South African Medical Research Council also played a major role in the success of the workshop. The local organising committee consisted of Dr Martin Nyaga (host, convener and chair), Dr Saheed Sabiu (secretary), and Mr Stephanus Riekert (principal ICT support).

News Archive

Scientists discover a water reservoir beneath the Free State
2009-12-09

Dr Holger Sommer

The Mantle Research Group Bloemfontein (MRGB), under the leadership of Dr Holger Sommer, a senior lecturer in the Department of Geology at the University of the Free State (UFS), has discovered an enormous water reservoir 160 km beneath the Free State.

This discovery, according to Dr Sommer, is the first of its kind in South Africa after he had previously made a similar finding in Colorado, USA.

However, this water cannot be used for human consumption. “It is not frozen water; it is not molecular water; it is not fresh water; it is not salty water; it is OH – water which is sitting in the crystal lattice,” he said.

He said the reservoir was comparable in size to Lake Victoria in Tanzania.
The researchers collected eclogites from the Roberts Victor (Rovic) Mine close to the town of Boshof, south-west of the Free State, for their study.

“The Rovic eclogites are rocks which represent former oceanic crust transported into the earth’s interior by complex plate tectonic processes about 2.0 billion years ago,” explained Dr Sommer.

“These rocks were finally carried back to the earth’s surface by volcanic (kimberlite) eruptions around 130 million years ago. Eclogitic rocks are therefore a window into the Earth’s interior.”

The question from the beginning for all MRGB scientists was: Is there water inside these rocks in such depth, and if so, where is it located?

To answer this question, Dr Sommer and his research fellows separated single mineral grains from eclogite samples and prepared about 100 micrometer (0,1 mm) thick rock sections. Afterwards, specific particle accelerator (Synchrotron) measurements were carried out in the city of Karlsruhe in Germany.

“And indeed, the MRGB found water inside the studied rocks from the Roberts Victor Mine,” he said. “The water was located in defect structures in crystal lattices and along boundaries between single mineral grains.”

“The occurrence of water at such depth would give first evidence that all water of the oceans could be stored five to ten times in the earth’s mantle.”
The study was conducted about a year ago.
 

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
4 December 2009

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