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19 July 2018 Photo Supplied
AEVGI advances Next-Generation Sequencing in Africa
Prof George Armah, Noguchi Memorial Institute for Medical Research, Ghana; Prof Carl Kirkwood, Bill and Melinda Gates Foundation, USA; Cornelius Hagenmeier, Director: Internationalisation, UFS; Prof Gert van Zyl, Dean: Health Sciences; Dr Martin Nyaga, Senior Lecturer in the NGS Unit; Prof Joyce Tsoka-Gwegweni, Vice-Dean: Health Sciences; Dr Glen Taylor, Senior Director: Research and Development; Prof Jeffrey Mphahlele, Vice-President, South African Medical Research Council.

The inaugural edition of the University of the Free State (UFS) Next-Generation Sequencing (NGS) Data and Bioinformatics Workshop, hosted by the UFS-NGS Unit in the UFS Faculty of Health Sciences, marked a new beginning for the advancement of NGS in Africa under the auspices of the African Enteric Viruses Genome Initiative (AEVGI), which was recently funded by the Bill and Melinda Gates Foundation.

The AEVGI will generate rotavirus genomes at the UFS-NGS Unit to investigate the long-term effects of the introduction of the monovalent RV1 vaccine in three African countries – Ghana, Malawi, and South Africa.

The workshop attracted over 90 participants from 15 national and international institutions, with organisations from seven different countries as well as company representatives attending the event. The workshop kicked off with a courtesy call to the Rector and Vice-Chancellor, Prof Francis Petersen, followed by a stakeholder meeting with the executive management of the UFS.

The funding was secured through an award to the principal investigator, Dr Martin Nyaga, and sub-awards to co-investigators, Dr Khuzwayo Jere, Dr Francis Dennis, and Dr Valentine Ndze. According to attendee evaluations of the workshop, the remarkable performance of the workshop instructors was outstanding. Through practical sessions, participants were equipped with knowledge on how to apply several tools of genetic data analysis, using the rotavirus genome as a model to construct and interpret different genomic datasets.

A total of 65 students attended the hands-on workshop, the majority of which were from South African higher-education institutions. The organisers are grateful to the sponsors, particularly to the Bill and Melinda Gates Foundation and the University of the Free State, for making the workshop a success. Whitehead Scientific and the South African Medical Research Council also played a major role in the success of the workshop. The local organising committee consisted of Dr Martin Nyaga (host, convener and chair), Dr Saheed Sabiu (secretary), and Mr Stephanus Riekert (principal ICT support).

News Archive

Tiny microbes may solve large problems of water contamination, says Prof Esta van Heerden
2014-12-08

Small solutions for big problems

According to Prof Esta van Heerden, professor in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS), this might hold some truth in current terms of water treatment strategies for waste and industrial effluents.

“There is little doubt in popular literature that eminent water crises are looming, not only with respect to the supply, but quality and effectiveness of various treatment options as well. The UFS’s Department of Microbial, Biochemical and Food Biotechnology is partnering with the Technology Innovation Agency to evaluate water treatment technologies that are applied worldwide and to extend these new or adapted options to innovative and interested clients in South Africa,” says Prof Van Heerden.

“The research focuses on using extreme microbes to tackle big contaminations and the results are amazing,” says Prof Van Heerden.

These microbes are fast becoming the stars on sites and developing these exciting systems allows for greener treatment options. It is fascinating that they can deal with metals, including chromium and uranium, cyanide, petroleum and diesel.

Of utmost importance is the development of a treatment for acid mine drainage.

“Interests have been overwhelming and thus far partners have allowed pilot scale development on their sites with very promising results. These initiatives are driven by responsible partners who strive to be innovative and develop sustainable technologies for good quality water that can be released in the environment,” Prof Van Heerden says.

The research group has set up a pipeline to serve the water communities’ needs. It provides an accessible toolkit for water analysis. A tailor-made treatment option is also developed and showcased in the laboratories. It has the added benefit that Geosyntec Consultants, USA, will ensure faster roll-out by sharing their vast experience on any related aspects.

 

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