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19 July 2018 Photo Supplied
AEVGI advances Next-Generation Sequencing in Africa
Prof George Armah, Noguchi Memorial Institute for Medical Research, Ghana; Prof Carl Kirkwood, Bill and Melinda Gates Foundation, USA; Cornelius Hagenmeier, Director: Internationalisation, UFS; Prof Gert van Zyl, Dean: Health Sciences; Dr Martin Nyaga, Senior Lecturer in the NGS Unit; Prof Joyce Tsoka-Gwegweni, Vice-Dean: Health Sciences; Dr Glen Taylor, Senior Director: Research and Development; Prof Jeffrey Mphahlele, Vice-President, South African Medical Research Council.

The inaugural edition of the University of the Free State (UFS) Next-Generation Sequencing (NGS) Data and Bioinformatics Workshop, hosted by the UFS-NGS Unit in the UFS Faculty of Health Sciences, marked a new beginning for the advancement of NGS in Africa under the auspices of the African Enteric Viruses Genome Initiative (AEVGI), which was recently funded by the Bill and Melinda Gates Foundation.

The AEVGI will generate rotavirus genomes at the UFS-NGS Unit to investigate the long-term effects of the introduction of the monovalent RV1 vaccine in three African countries – Ghana, Malawi, and South Africa.

The workshop attracted over 90 participants from 15 national and international institutions, with organisations from seven different countries as well as company representatives attending the event. The workshop kicked off with a courtesy call to the Rector and Vice-Chancellor, Prof Francis Petersen, followed by a stakeholder meeting with the executive management of the UFS.

The funding was secured through an award to the principal investigator, Dr Martin Nyaga, and sub-awards to co-investigators, Dr Khuzwayo Jere, Dr Francis Dennis, and Dr Valentine Ndze. According to attendee evaluations of the workshop, the remarkable performance of the workshop instructors was outstanding. Through practical sessions, participants were equipped with knowledge on how to apply several tools of genetic data analysis, using the rotavirus genome as a model to construct and interpret different genomic datasets.

A total of 65 students attended the hands-on workshop, the majority of which were from South African higher-education institutions. The organisers are grateful to the sponsors, particularly to the Bill and Melinda Gates Foundation and the University of the Free State, for making the workshop a success. Whitehead Scientific and the South African Medical Research Council also played a major role in the success of the workshop. The local organising committee consisted of Dr Martin Nyaga (host, convener and chair), Dr Saheed Sabiu (secretary), and Mr Stephanus Riekert (principal ICT support).

News Archive

UFS lecturer serves on National Forensic Oversight and Ethics Board
2015-02-13

Dr Karin Ehlers

Dr Karin Ehlers, lecturer in the Department of Genetics at the University of the Free State, was elected by the Minister of Police, Mr Nkosinathi Nhleko, to serve on the National Forensic Oversight and Ethics Board which will, among others, monitor the implementation of the provisions of the DNA Act.

Previously, when DNA evidence was collected at a crime scene, it was analysed only when requested by the prosecutor or investigator when they had found a suspect and needed confirmation. With the new DNA Act, all samples collected from violent crimes must be analysed. The profiles will be compared with a convicted offender database to see if some of the unsolved cases can be linked to these perpetrators. The reason for this is that many of these offenders are repeat offenders, and this process will increase the chances of solving cases successfully.

Serving on the Board, Dr Ehlers will also have the opportunity to contribute to proposals on:
- the improvement of practices regarding the overall operations of the National Forensic DNA Database (NFDD),
- the ethical, legal, and social implications of the use of forensic DNA profiles, and
- the training and the development of criteria for the use of familial searches.

Board members will also receive and assess complaints about alleged violations relating to the abuse of DNA samples and forensic DNA profiles and/or security breaches, and will report to complainants in respect thereof.

In 2014, when all citizens in South Africa were invited to apply for a position on the National Forensic Oversight and Ethics Board, Dr Ehlers submitted her application with a motivation on how she could contribute to the function of the Board. She is one of ten persons who were appointed to serve on the Board. “The reason I was successful was due to my involvement in the development of the UFS Forensic Sciences Programme,” Dr Ehlers said.

The capacity of the country was one of the challenges that had to be overcome for this Act to take effect. ”The UFS was able to address this problem, implementing degrees in Forensic Genetics and Forensic Sciences. With these programmes we made a real difference in the fight against crime. It is a real privilege to form part of this project,” said Dr Ehlers.

Dr Karin Ehlers serves on National Forensic Oversight and Ethics Board (read the full story)

 

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