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19 July 2018 Photo Supplied
AEVGI advances Next-Generation Sequencing in Africa
Prof George Armah, Noguchi Memorial Institute for Medical Research, Ghana; Prof Carl Kirkwood, Bill and Melinda Gates Foundation, USA; Cornelius Hagenmeier, Director: Internationalisation, UFS; Prof Gert van Zyl, Dean: Health Sciences; Dr Martin Nyaga, Senior Lecturer in the NGS Unit; Prof Joyce Tsoka-Gwegweni, Vice-Dean: Health Sciences; Dr Glen Taylor, Senior Director: Research and Development; Prof Jeffrey Mphahlele, Vice-President, South African Medical Research Council.

The inaugural edition of the University of the Free State (UFS) Next-Generation Sequencing (NGS) Data and Bioinformatics Workshop, hosted by the UFS-NGS Unit in the UFS Faculty of Health Sciences, marked a new beginning for the advancement of NGS in Africa under the auspices of the African Enteric Viruses Genome Initiative (AEVGI), which was recently funded by the Bill and Melinda Gates Foundation.

The AEVGI will generate rotavirus genomes at the UFS-NGS Unit to investigate the long-term effects of the introduction of the monovalent RV1 vaccine in three African countries – Ghana, Malawi, and South Africa.

The workshop attracted over 90 participants from 15 national and international institutions, with organisations from seven different countries as well as company representatives attending the event. The workshop kicked off with a courtesy call to the Rector and Vice-Chancellor, Prof Francis Petersen, followed by a stakeholder meeting with the executive management of the UFS.

The funding was secured through an award to the principal investigator, Dr Martin Nyaga, and sub-awards to co-investigators, Dr Khuzwayo Jere, Dr Francis Dennis, and Dr Valentine Ndze. According to attendee evaluations of the workshop, the remarkable performance of the workshop instructors was outstanding. Through practical sessions, participants were equipped with knowledge on how to apply several tools of genetic data analysis, using the rotavirus genome as a model to construct and interpret different genomic datasets.

A total of 65 students attended the hands-on workshop, the majority of which were from South African higher-education institutions. The organisers are grateful to the sponsors, particularly to the Bill and Melinda Gates Foundation and the University of the Free State, for making the workshop a success. Whitehead Scientific and the South African Medical Research Council also played a major role in the success of the workshop. The local organising committee consisted of Dr Martin Nyaga (host, convener and chair), Dr Saheed Sabiu (secretary), and Mr Stephanus Riekert (principal ICT support).

News Archive

UFS venture cleans up acid mine drainage
2015-07-06

The system that puts oxygen back into the water.

Photo: Supplied

South Africa is one of the most important mining countries in the world, beginning in the 1870s. Although the mining industry has been responsible for significant development and employment, it pollutes the environment and waters sources. Through the joint effort of a well-known mining company, the University of the Free State, and the Technology Innovation Agency (UFS/TIA) SAENSE Group, a new treatment for Acid Mine Drainage (AMD) has been developed.

The system treats the major contaminants found in acid mining wastewater effectively.  
 
The UFS remediation systems use a reservoir tank into which the AMD is pumped. The water then flows passively (without using energy) to the Barium Carbonate Dispersed Alkaline Substrate (BDAS) system. The metals and anions in the AMD react chemically with the barium carbonate and precipitate (form solids). The solids stay in the tank while the clean water is released.

The efficacy and applicability of the research was demonstrated on site in Belfast, Mpumalanga where the team constructed a pilot plant in July 2014. This patented technology has treated 1 814 400 litres of Acid Mine Drainage to date with an outflow water quality that satisfies the South African National Standards (SANS) 241:2006 & 2011 regulations for drinking water.   

Rohan Posthumus from the (UFS/TIA) SAENSE Group said: “At this stage, we do not recommend that the water should be used as drinking water, but certainly it can lower water usage in mines while finding application in dust suppression of washing processes. The team would like to complete a full characterisation of the final released water. There are currently no toxic by-products formed, and even very basic filtration can make the outflow drinking water.”

Prof Esta van Heerden’s research group from the Department of Microbial, Biochemical, and Food Biotechnology has been working on AMD research for some time, but the development of the BDAS system was started in 2013 by post-doctoral student, Dr Julio Castillo, and his junior researcher, Rohan Posthumus.

The data from the BDAS system have led to two publications in peer-reviewed journals as well as a registered patent.

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