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14 June 2018 Photo Supplied
Next Chapter Green Ribbon campaign addresses mental health
Members of Next Chapter and UFS Student counselling are working together to address mental health issues.

Next Chapter, a student support group at the UFS presented the Green Ribbon campaign, pledging their support to students and providing them with assistance in coping with life events that stimulate stress and contribute negatively to their mental health. The team aims to break the stigma surrounding mental health care, and continually assist students with mental health-related issues that they struggle with daily.

The Green Ribbon represents mental health awareness, which is a pressing matter for students and is the type of support students need in a stressful university environment. The campaign focuses on teaching students how to cope with life events that stimulate stress, and contribute negatively to their mental health.
 
A discussion by Dr Ancel George: practising clinical psychologist and lecturer from the UFS Department of Psychology, and Dr Mellissa Barnaschone: Director of UFS Student Counselling, took place, where talks were prominent about creating an inclusive environment for UFS students.

The panel shared a few tips on how students should work towards managing stress, and motivated them for the main mid-year examinations.
 
The follow-up Exam Cram Workshop, presented by Nadia Cloete and Lize Wolmarans, that combined time and stress management, took place on 2 June 2018, and saw students receiving advice on how to approach various issues during the examination period.
 
Mental health awareness does not end with the campaign and Next Chapter’s slogan “Your story continues” encourages students to regularly wear and commemorate the green ribbon in support of continual mental healthcare.
 
Should you have any enquiries or input for the ongoing campaign, contact the Next Chapter team on ufsnextchapter@gmail.com, or further email Tshepang Mahlatsi, founder of Next Chapter on tshepangmahlatsi767@gmail.com

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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