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07 June 2018 Photo Prof CB Bousman, from Texas State University.
Quaternary International volume dedicated to UFS research fellow
Dr James Brink visits the Erfkroon site on the Modder River in the Free State.

The contents of a special issue of Quaternary International (QI), consisting of 13 articles and contributions by 45 authors (25 from abroad), was recently presented to Dr James Simpson Brink. The papers represent the broad range of topics covered by Dr Brink’s research interests.  

The special issue of QI was initiated to coincide with James Simpson Brink’s 60th birthday after he recently celebrated 35 years of ground-breaking research at the National Museum of Bloemfontein.

Dr Brink is affiliated to the Centre for Environmental Management at the University of the Free State (UFS).

Prof Louis Scott, researcher in the Department of Plant Sciences at the UFS, was the executive guest editor, and was part of a team of three guest editors (Dr Liora Horwitz from the Hebrew University in Jerusalem, and Dr Daryl Codron from the National Museum in Bloemfontein) who worked on this special issue of the journal, QI. 

In honour of a friend and colleague
“Dr Brink made contributions to osteology, Quaternary palaeontology, and archaeozoology, by investigating the environments and mechanisms that drove the evolution of mammal communities of southern Africa,” said the guest editors. 

“By studying the morphology of the endemic black wildebeest he demonstrated how the species evolved in the central interior of South Africa. He pioneered descriptions and dating of faunal assemblages that make up the so-called ‘Cornelian’ and ‘Florisian’ Land Mammal Ages. In this way he reconstructed the long history of environments in which Stone Age occupants survived in the region. The work included the age determination of the cranium with facial bones of an individual who lived at Floribad around 250 000 years ago.

Work enabled more important studies
“Dr Brink contributed more than purely academic insights in that he built and curated the modern mammal and fossil faunal collections of the Florisbad Quaternary Research Station. These collections made it possible for researchers, who came from all over the world, to visit the Free State and focus on spatial and temporal palaeoenvironmental trends. Apart from contributing to the functional diversity of mammalian species, this enabled the investigation of morphological and behavioural variations across populations and communities,” said the editors.

The topics of the papers in this special issue of QI are interdisciplinary and include different methods in archaeology, vertebrate palaeontology and past (or palaeo-) environmental reconstruction. The ages dealt with range from the relatively recent Iron Age to the Oldowan period, which is over a million years old.

According to Prof Scott, with a degree of overlap in the interdisciplinary fields studied, the papers can be arranged into 1) taphonomy and archaeozoology, relating to the processes resulting in the formation and preservation of fossil material in archaeological sites, 2) Stone Age archaeology, dealing with artefacts, stratigraphy and palaeoanthropology, and 3) palaeoecology, that includes palaeontology, isotope studies and palaeoenvironmental reconstructions.

The journal, published by Elsevier, will be distributed worldwide. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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