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07 June 2018 Photo Prof CB Bousman, from Texas State University.
Quaternary International volume dedicated to UFS research fellow
Dr James Brink visits the Erfkroon site on the Modder River in the Free State.

The contents of a special issue of Quaternary International (QI), consisting of 13 articles and contributions by 45 authors (25 from abroad), was recently presented to Dr James Simpson Brink. The papers represent the broad range of topics covered by Dr Brink’s research interests.  

The special issue of QI was initiated to coincide with James Simpson Brink’s 60th birthday after he recently celebrated 35 years of ground-breaking research at the National Museum of Bloemfontein.

Dr Brink is affiliated to the Centre for Environmental Management at the University of the Free State (UFS).

Prof Louis Scott, researcher in the Department of Plant Sciences at the UFS, was the executive guest editor, and was part of a team of three guest editors (Dr Liora Horwitz from the Hebrew University in Jerusalem, and Dr Daryl Codron from the National Museum in Bloemfontein) who worked on this special issue of the journal, QI. 

In honour of a friend and colleague
“Dr Brink made contributions to osteology, Quaternary palaeontology, and archaeozoology, by investigating the environments and mechanisms that drove the evolution of mammal communities of southern Africa,” said the guest editors. 

“By studying the morphology of the endemic black wildebeest he demonstrated how the species evolved in the central interior of South Africa. He pioneered descriptions and dating of faunal assemblages that make up the so-called ‘Cornelian’ and ‘Florisian’ Land Mammal Ages. In this way he reconstructed the long history of environments in which Stone Age occupants survived in the region. The work included the age determination of the cranium with facial bones of an individual who lived at Floribad around 250 000 years ago.

Work enabled more important studies
“Dr Brink contributed more than purely academic insights in that he built and curated the modern mammal and fossil faunal collections of the Florisbad Quaternary Research Station. These collections made it possible for researchers, who came from all over the world, to visit the Free State and focus on spatial and temporal palaeoenvironmental trends. Apart from contributing to the functional diversity of mammalian species, this enabled the investigation of morphological and behavioural variations across populations and communities,” said the editors.

The topics of the papers in this special issue of QI are interdisciplinary and include different methods in archaeology, vertebrate palaeontology and past (or palaeo-) environmental reconstruction. The ages dealt with range from the relatively recent Iron Age to the Oldowan period, which is over a million years old.

According to Prof Scott, with a degree of overlap in the interdisciplinary fields studied, the papers can be arranged into 1) taphonomy and archaeozoology, relating to the processes resulting in the formation and preservation of fossil material in archaeological sites, 2) Stone Age archaeology, dealing with artefacts, stratigraphy and palaeoanthropology, and 3) palaeoecology, that includes palaeontology, isotope studies and palaeoenvironmental reconstructions.

The journal, published by Elsevier, will be distributed worldwide. 

News Archive

#Women'sMonth: Save the children
2017-08-10

Description: Trudi O'Neill Tags: : rotaviruses, young children, Dr Trudi O’Neill, Department of Microbial, Biochemical and Food Biotechnology, vaccine 

Dr Trudi O’Neill, Senior lecturer in the Department of
Microbial, Biochemical and Food Biotechnology.
Photo: Anja Aucamp

Dr Trudi O’Neill, Senior lecturer in the Department of Microbial, Biochemical and Food Biotechnology, is conducting research on rotavirus vaccines.

Dr O’Neill was inspired to conduct research on this issue through her fascination with the virus. “The biology of rotaviruses, especially the genome structure and the virus’ interaction with the host, is fascinating.”

“In fact, it is estimated that, globally, ALL children will be infected with rotavirus before the age of five, irrespective of their socio-economic standing. However, infants and young children in poor countries are more vulnerable due to inadequate healthcare. The WHO estimates that approximately 215 000 deaths occur each year. This roughly equates to eight Airbus A380 planes, the largest commercial carrier with a capacity of approximately 500 seats, filled with only children under the age of five, crashing each week of every year.”

Alternative to expensive medicines 
“Currently, there are two vaccines that have been licensed for global use. However, these vaccines are expensive and poor countries, where the need is the greatest, are struggling to introduce them sustainably. It is therefore appealing to study rotaviruses, as it is scientifically challenging, but could at the same time have an impact on child health,” Dr O’Neill said.

The main focus of Dr O’Neill’s research is to develop a more affordable vaccine that can promote child vaccination in countries/areas that cannot afford the current vaccines.

All about a different approach 

When asked about the most profound finding of her research, Dr O’Neill responded: “It is not so much a finding, but rather the approach. My rotavirus research group is making use of yeast as vehicle to produce a sub-unit vaccine. These microbes are attractive, as they are relatively easy to manipulate and cheap to cultivate. Downstream production costs can therefore be reduced. The system we use was developed by my colleagues, Profs Koos Albertyn and Martie Smit, and allows for the potential use of any yeast. This enables us to screen a vast number of yeasts in order to identify the best yeast producer.”

Vaccination recently acquired a bad name in the media for its adverse side effects. As researcher, Dr O’Neill has this to say: “Vaccines save lives. By vaccinating your child, you don’t just protect your own child from a potentially deadly infection, but also other children in your community that might be too young to be vaccinated or have pre-existing health problems that prevents vaccination.” 

A future without rotavirus vaccination?

Dr O’Neill believes a future without rotavirus vaccination will be a major step backwards, as the impact of rotavirus vaccines has been profound. “Studies in Mexico and Malawi actually show a reduction in deaths. A colleague in Mozambique has commented on the empty hospital beds that amazed both clinicians and scientists only one year after the introduction of the vaccine in that country. Although many parents, mostly in developed countries, don’t have to fear dehydrating diarrhoea and potential hospitalisation of their babies due to rotavirus infection anymore, such an infection could still be a death sentence in countries that have not been able to introduce the vaccine in their national vaccination programmes,” she said. 

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