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09 March 2018 Photo Barend Nagel
Experts engage in stimulating discussion on South Africa future
Moeletsi Mbeki, Prof Phillippe Burger, Dr Ina Gouws, and Waldimar Pelser.

The University of the Free State (UFS) and the broader Bloemfontein community had the privilege of listening to expert opinions on the country’s future at the Wynand Mouton Theatre on the Bloemfontein Campus on 2 March 2018. On stage were Waldimar Pelser, Rapport editor; Prof Phillippe Burger (Department of Economics); Dr Ina Gouws (Department of Political Studies and Governance) from UFS; and author and businessman Moeletsi Mbeki. Together they painted a critical picture of our current and future state of affairs during a remarkable morning hosted by Rapport Regstreeks and kykNET. 

The ills of our economy
Master of his subject, Prof Burger had the audience spellbound when he explained the real issues surrounding our current sluggish economy. He was concerned about the general lack of growth – the major reason for unemployment. Figures have shown that even a slight increase in economic growth, creates an increase in employment. “We know that good education leads to economic growth,” he said. Poor education is one of our big problems, with our school mathematics performance among the worst in the world. He further advised that we should roll back patronage, stabilise public debt, facilitate a true partnership between government and businesses, identify specific growth sectors, address tenure rights, develop supply chains, and develop special skills. “I believe that we should bring back apprenticeships,” he said. 

Political pains
Mostly in agreement with Prof Burger’s contribution, Mbeki wanted to add politics in the mix as a factor that harms our economy. Capturing the audience with his impressive knowledge and insight, he explained that we basically still sat with the British economic systems set out between 1902 and 1910 – the production and export of minerals, fuelled by cheap labour. The mining sector provided a market for agriculture that also used cheap labour. Currently, we sit with two elites: the capital elite that produces, and the political elite that taxes the profits. Hence, the money is not reinvested. “We need new elite, that will invest in the country, instead of consuming the profits,” he said. Who should this be? “Such a coalition must include owners of productive assets who should form an alliance with rural people.”

Remain vigilant
Dr Ina Gouws supported this notion, saying that now was not the time to put our hopes in one leader for a better future. We should remain critical and vocal about our concerns. Political leaders did not always paint a true picture of what the people wanted and felt. 

More interesting and current topics were addressed during the question and answer session, and Pelser ensured that all adhered to a strict schedule, while using the available time optimally. We hope to see more such events on campus, inviting discourse on current topics. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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