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19 March 2018 | Story Eugene Seegers | Photo Charl Devenish
UFS collaborates with Wits UWC to present higher education PhD Conference
Prof Merridy Wilson-Strydom (UFS, Prof Patricio Langa (UWC), Prof Melanie Walker (UFS), and Prof Stephanie Allais (Wits) at the keynote address delivered by Prof Allais.

The higher education sector in Africa has seen dramatic shifts over the past few years, and has attracted renewed attention from global funders and national policy-makers. In turn, country-wide challenges of poverty, inequalities, and university histories and stratification in South Africa and elsewhere on the continent offer rich opportunities for critical, theoretically-informed research to investigate and understand the conditions of possibility for change nationally and comparatively.

In particular, three centres at universities in South Africa have decided to build an organic collaboration, starting with research by doctoral research fellows at these universities, who presented papers at a two-day conference. The conference was jointly organised and hosted under the umbrella of the SARCHi (South African Research Chairs Initiative) Chair in Higher Education and Human Development at the Bloemfontein Campus of University of the Free State (UFS). Two keynote addresses on significant issues in the sector were presented by Prof Stephanie Allais, Director of the Centre for Researching Education and Labour (REAL, University of the Witwatersrand) and Prof Patricio Langa, Associate Professor of Sociology and Higher Education Studies at the Institute for Post-School Studies (IPPS, University of the Western Cape).

HE researchers collaborate
This ongoing collaboration between the three universities was initiated by Prof Melanie Walker at the UFS, in partnership with Prof Allais and Prof Langa and their institutions, with each institution taking a turn to host similar conferences. The conference at the UFS not only brought together doctoral researchers from these three centres to share their research, but it also offered the opportunity to engage with other early-career and experienced scholars. 

The conference was themed Critical Higher Education Studies: Theories and Research and aimed to build research relationships and stimulate debate among scholars. It was jointly organised by postdoctoral fellows: Ntimi Mtawa and Faith Mkwananzi (UFS), Bothwell Manyonga (Wits), and Patrick Swanzy (UWC).

Significant benefits for conference-goers and presenters alike

Conference-goers, as well as the presenters, reported great benefits as a result of their attendance and participation in the event. The research papers were important and central. However, the broader value of the conference was the platform it offered to young, emerging scholars to showcase their research projects, receive critical comments, listen and learn from one another, in addition to engaging with experienced scholars. 

Secondly, the variety of PhD research fellows who presented their research further enhanced critical academic engagement and the exchange of ideas. Presenters reported that the quality of feedback and comments on their projects had especially enhanced their current work. The focus of the stimulating keynote addresses also challenged participants to think well and critically about the field of higher education. Practical skills development also featured on the programme in the form of learning how to present a TED-style talk.

“The conference was especially valuable in bringing together early-career researchers working on critical and theorised approaches to higher education,” said Prof Walker. She added, “In particular, I valued the diversity of both the projects and their theoretical frames, which proved especially rich, together with the outstanding keynote contributions—one from political economy and one from sociology—which shaped the event as a whole.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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