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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology

The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

UFS Physics Research Chair receives more funding
2017-11-20


 Description: Prof Hendrik Swart, Physics Research Chair receives more funding Tags: Prof Hendrik Swart, Physics Research Chair receives more funding

Prof Hendrik Swart, Senior Researcher Professor in the
Department of Physics at UFS.
Photo: Charl Devenish

A research project into low-energy lighting using phosphor materials for light emitting diodes (LEDs) at the Department of Physics at the University of the Free State (UFS) has received further recognition. 

The South African Research Chairs Initiative (SARChi) has awarded further funding for the Research Chair in Solid State Luminescent and Advanced Materials situated in the department. Prof Hendrik Swart, a Senior Research Professor in the Department of Physics, says this means that the Chair will carry on receiving funds from SARChi for another five years. The Initiative also awarded Prof Swart in 2012 for the research, which resulted in funding for equipment and among others, bursaries.    

Better light emission in LED’s
The research focuses on better light emission of phosphor powers in LEDs. It is also looking into improving LED displays in flat screens. The research into solar cells has shown that phosphors can also increase their efficiency by increasing the range of light frequencies, which convert into electricity. It also entails that glow-in-the-dark coatings absorb light during the day and emit it at night. 

Prof Swart says over the next five years the research will focus on developing and producing devices that emit better light using the substances already developed. “We need to make small devices to see if they are better than those we already have.” In practical terms, it means they want a farmer’s water pump that works with solar energy to work better with less energy input.” 

Device that simulates sunlight
Prof Swart says the renewal of the Chair’s funding means the department can now get equipment to enhance its research   such as a solar simulator. The solar simulator uses white LEDs whose intensity output and wavelengths can be tuned. The output is measured in number of suns. It enables researchers to work in a laboratory with a device that simulates sunlight.     

According to Prof Swart the long-term benefit of the research will result in more environmentally friendly devices which use less energy, are brighter and give a wider viewing field. 

About 10 postdoctoral researchers are working on the studies done by the Chair in collaboration with the Council for Scientific and Industrial Research. 

The Research Chair Initiative aims to improve the research capacity at public universities to produce high-quality postgraduate students, research and innovative outputs. The criterion for evaluating the department’s Chair includes aspects such as how much development has occurred over the past five years. The assessors look at features such as the number of students the research entity has trained and how many publications the research team has produced.

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