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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

Students excel in legal interpreting programme
2010-02-24

Prof. Ezekiel Moraka, Vice-Rector: External Relations at the UFS with one of the students who received a diploma.
Photo: Mangaliso Radebe


A success rate of 90% was achieved by the first group of 100 students that successfully completed the two-year Diploma in Legal Interpreting at the University of the Free State (UFS).

The group recently received their diplomas at the ceremony held on the Main Campus in Bloemfontein.

The programme, offered by the university’s Department of Afroasiatic Studies, Sign Language and Language Practice, in collaboration with the Department of Justice and Constitutional Development and Safety and Security Sector Education and Training Authority (SASSETA), is the only one of its kind in South Africa.

“The numbers that we are talking about here, if one looks at the needs of the country as such, is a small fraction,” said Advocate Simon Jiyane, Deputy Director General: Court Services in the Department of Justice.

“This is our first programme in collaboration with the UFS and I am hopeful it will lay a very solid foundation for other such programmes to follow.”

The diplomas were conferred by Prof. Ezekiel Moraka, Vice-Rector: External Relations at the UFS, on behalf of the Rector and Vice-Chancellor, Prof. Jonathan Jansen.

He urged the students to use their skills as qualified court interpreters in the context of the challenges that face South Africa such as HIV/Aids, racism, transformation, unemployment, poverty, job losses, and many other such challenges.

“This is the reality we are faced with, all of us,” he said. “It requires skilful and morally upright people to address it adequately and effectively. You are adding up to the number of skilful people in our country and that means you have a critical role to play.”

He said the UFS, as a societal structure, is equally affected by those challenges because of being accountable to and economically dependent on society.

He also urged the students to use their skills to make contributions to the processes of transformation that are underway at the UFS.

“For instance, the UFS as a national asset has to transform to that level of being a true national asset. We need your full participation in this process so that we can together ensure the relevance of this university as a true South African university,” he said.

Advocate Jiyane urged universities to also look at some of the initiatives that the government takes to improve service delivery. One such initiative is a pilot project focusing on the use of indigenous languages in courts.

“Its aim is to ensure that our courts begin to recognise all official languages in terms of conducting their business,” he said.

“It is our responsibility as a department that, through this project, we begin to build those languages so that they are on a par with the other languages that are being utilised in our courts.”

The department has permanently employed two of the students who received their diplomas, while one of them, Ms Nombulelo Esta Meki, was awarded a bursary by SASSETA to study for a BA in Legal Interpreting. Ms Meki was the top achiever of the programme with an average of 86%.

Media Release:
Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
3 March 2010

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