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Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

UFS Council votes on top appointments
2003-11-24

The Council of the University of the Free State (UFS) today voted on the filling of four senior vacancies, including three posts at Vice-Rector level and one at the level of Dean.

The Council voted as follows:
- Prof Magda Fourie will be offered the post of Vice-Rector: Academic Planning
- Dr Ezekiel Moraka will be offered the post of Vice-Rector: Student Affairs
- Prof Teuns Verschoor will be offered the post of Vice-Rector: Academic Operations
- Prof Letticia Moja will be offered the post of Dean: Faculty of Health Sciences

Two of the candidates, Prof Teuns Verschoor and Prof Magda Fourie, are currently acting Vice-Rectors at the UFS. Prof Verschoor is acting Vice-Rector for Student Affairs and Prof Fourie is acting Vice-Rector for Academic Planning. Dr Moraka is currently Dean of Student Affairs at the University of Pretoria (UP). Prof Moja is currently the acting Dean of the Faculty of Health Sciences at the UFS.

According to the Rector and Vice-Chancellor of the UFS, Prof Frederick Fourie, the filling of these senior vacancies comes after one of the most thorough search and selection processes ever at the UFS.

“It is wonderful that we are able to celebrate the outcome of this process that has brought forward such excellent candidates who reflect our country’s diversity. It shows that we can achieve the goals of quality and diversity at the same time,” Prof Fourie said.

Prof Magda Fourie (49) received her Ph D on Institutional governance of higher education in transition: a South African perspective from the UFS in 1996. She joined the UFS in 1998, later becoming Director of the Centre for Higher Education Studies and Development and Professor in Higher Education Studies. She said in her declaration of intent her aspiration is to contribute to making the UFS the excellent university it foresees in its vision and mission. Academic planning should position the UFS with regard to its core activities strategically as an institution of excellence that will meet the future from a strong basis of academic integrity and credibility.

Dr Moraka (45) received his Ph D in Education Management on Management of change and conflict resolution by student affairs officers at historically white universities in South Africa from the UP in 2002. He is Dean of Students at the UP since 2001. Before that he was Head of Student Support and Student Social Services at the UP for six years. He was also, among others, a lecturer at a college of education and a pastor of the Dutch Reformed Church in Africa. He said in his declaration of intent that diversity can become so greatly emphasised that people can be driven further apart. Focus should be on moulding a student community where everyone can feel at home, a community which lives together and works together without destroying what is unique to each individual.

Prof Verschoor (53) received his LL D in 1980 at the University of Pretoria on The criminal responsibility of psychopaths and similar figures. He was professor in and Head of the Department of Criminal Law and Medical Law at the UFS for 17 years before becoming Dean of Students in 1994. He said in his declaration of intent that he dreams of the realisation of projects that are awaiting the enthusiastic support, bringing together and empowering of persons involved by a Vice-Rector that wants to see the UFS prosper in an era of continuing dynamic development. In this he would like to make a substantial contribution.

Prof Moja (46) received her MB ChB in 1982 from the University of Natal and her M.Med in Obstetrics and Gynecology in 1990 from the Medical University of South Africa (Medunsa). She became a full professor in 2003 at the UFS and has been acting as Dean of the UFS’s Faculty of Health Sciences since February 2003. She said in her declaration of intent that the challenge for her is to manage change with the ultimate aim of both achieving the vision of the UFS and satisfying the needs of the community. Some of the academic challenges include the training of more people from designated groups and rural areas. Careful planning and integration of the curriculum should be done to ensure that all students perform to their best.

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