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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology

The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

School of Open Learning opens access to education
2011-12-08

 

Lanterns filled the night sky as UFS staff and guests celebrate the launch of the School of Open Learning at the university’s South Campus.
Photo: Johan Pretorius

A school which intends to expand the boundaries of the University of the Free State (UFS), providing good quality higher education that is based on open learning principles. That is what the School of Open Learning at the UFS’ South Campus is all about. The School was officially launched at the Campus on 28 November 2011. 

Prof. Daniella Coetzee, Dean of the School, told guests at the launch that the School will provide opportunities other than traditional learning in higher education and open up access to those who have not had the opportunity to study at a higher education institution. This includes taking programmes and courses to students at off-campus sites. The School of Open Learning currently has 46 off-campus sites across most of the provinces, i.e. Mpumalanga, KwaZulu-Natal, North West, Eastern Cape, Northern Cape, Limpopo and the Free State. The off-campus sites are serviced by a total of 350 university lecturers and well-trained facilitators and tutors.
 
At the moment most of the programmes and courses managed by the School of Open Learning have their academic home in the Faculty of Education, providing upgrading of the qualifications of teachers as well as in-service training. In 2011 the School of Open Learning enrolled more than 4000 students for the Education courses. To date a total of 28 000 teachers have been enrolled at the School to upgrade their teaching qualifications.
 
Collaboration with the Faculty of Law in the presentation of a BIuris degree on off-campus sites is also on the calendar for 2012. This degree will be offered through contact and E-learning at three off-campus sites: Johannesburg, Durban and Cape Town.
 
The University Preparation Programme (UPP) will also form part of the School of Open Learning. This programme has proven to be extremely successful in providing students access to undergraduate degrees at the UFS. The curriculum for this bridging year offers courses from the Faculties of Economic and Management Sciences, Human and Social Sciences as well as Natural and Agricultural Sciences. Since 1993 more than 4500 students have enrolled for degree purposes after successfully completing the UPP: 1641 degrees have been awarded to students who began their studies in the programme (including 168 honours degrees; 25 master’s and 8 M.B.Ch.B. degrees). The existing foundation course in the UPP is being adapted to also serve NQF level 4 in further education. As far back as 1998, the Sunday Times (Best in Education, 1998:1) named this programme as “one of the most innovative education programmes” in a special supplement on higher education in South Africa.
 
Also speaking at the event, Prof. Jonathan Jansen, Vice-Chancellor and Rector, said the South Campus is to become intellectually alive with possibilities. He said the university will make sure there are seminars, conferences and classes where students can mingle across the university’s three campuses.

 

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