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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

Renowned writer for Africa Day
2012-05-31

 

Attending the lecture were, from left: Dr Choice Makhetha, Vice-Rector: External Relations; Prof Kwandiwe Kondlo, Director of the Centre for Africa Studies;Prof. Ngugi wa Thiong'o; Prof Lucius Botes, Dean of the Faculty of the Humanities, and Prof Andre Keet, Director of the Institute for Reconciliation and Social Justice..
Photo: Stephen Collett
25 May 2012

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Lecture: THE BLACKNESS OF BLACK: Africa in the World Today

Audio of the lecture

Profile of Professor Ngugi wa Thiong'o (pdf format)

“Flowers are all different, yet no flower claims to be more of a flower than the other.” With these words Kenyan writer and one of the continent's most celebrated authors, Prof. Ngugi wa Thiong’o, delivered the tenth annual Africa Day Memorial lecture on 25 May 2012 in the University of the Free State's (UFS) Odeion Theatre on the Bloemfontein Campus. The lecture was hosted by the Centre for Africa Studies.

Long before Prof. wa Thiong’o was led inside the venue by a praise singer, chairs were filled and people were shown to an adjoining room to follow the lecture. Others, some on the university's Qwaqwa Campus, followed via live streaming.

In his speech titled the Blackness of Black: Africa in the world today, Prof. wa Thiong’o looked at the standing of Africa in the world today. He highlighted the plight of those of African descent who are judged “based on a negative profile of blackness”.

Prof. wa Thiong’o recalled a humiliating experience at a hotel in San Francisco in the United States, where a staff member questioned him being a guest of the hotel. He shared a similar experience in New Jersey, where he and his wife were thought to be recipients of welfare cheques. He said this was far deeper than overt racism.

“The certainty is based on a negative profile of blackness taken so much for granted as normal that it no longer creates a doubt.”

Prof. wa Thiong’o said the self certainty that black is negative is not confined to white perception of black only.

“The biggest sin, then, is not that certain groups of white people, and even the West as a whole, may have a negative view of blackness embedded in their psyche, the real sin is that the black bourgeoisie in Africa and the world should contribute to that negativity and even embrace it by becoming participants or shareholders in a multibillion industry built on black negativity.”

“Africa has to review the roots of the current imbalance of power: it started in the colonisation of the body. Africa has to reclaim the black body with all its blackness as the starting point in our plunge into and negotiations with the world.”

Prof. wa Thiong’o concluded by saying that Africa must rediscover and reconnect with Kwame Nkrumah’s dreams of a politically and economically united Africa.

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