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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

Science and goodwill meet drought-stricken communities
2016-03-02

Description: Disinfecting tankered water  Tags: Disinfecting water

“Everyone should contribute to the delivery of clean water to every individual,” says UFS researcher.

The drought in South Africa has impacted the country in many ways. Apart from its economic and environmental implications, the drought also has social implications, leaving some communities without water.

Since 21 January 2016, the Department of Water and Sanitation (DWS) is working together with the Department of Microbial, Biochemical, and Food Biotechnology at the University of the Free State. Dr Mariana Erasmus, post-doctoral fellow in the department, was appointed to lead a project for disinfecting tankered water supplied by the DWS to communities without water in the Qwaqwa area - which falls under the Maluti-a-Phufung Local Municipality.

She is working on the project with Robbie Erasmus from BioSense Solutions and Martin Bambo from DWS. A total of 53 trucks, 91 tanks, and 420 500 litres of water was disinfected so far, using sodium hypochlorite. “This is standard practice around the world,” Dr Erasmus said.

The work done by the UFS and DWS, who is monitoring the water quality as well as the process of water delivery, is very important. Disinfecting the trucks used to deliver water to drought-stricken communities decreases the formation of biofilm inside the tanks. “The biofilm could contain harmful bacteria such as E-coli. It is important to note that this is mostly the result of secondary pollution, since the water quality from the source where it was taken from, proved to be good. Drinking water with this harmful bacteria that has not been properly managed, can lead to health issues in humans when consumed,” Dr Erasmus said.

The Department of Microbial, Biochemical, and Food Biotechnology, interacting with the DWS on several water-related issues, volunteered to get involved in the project. They strongly believe that everyone should contribute to the delivery of clean water to every individual.

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