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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

SADoCoL receives partial reinstatement of blood sample testing by the World Anti-Doping Agency
2016-08-22

Last week, the World Anti-Doping Agency (WADA) announced the lifting of the suspension of blood sample analysis by the South African Doping Control Laboratory (SADoCoL) at the University of the Free State (UFS). Although the suspension of urine sample analysis is still under review, the UFS is appreciative of the new outcome. The initial temporary suspension of SADoCoL, announced on 3 May 2016, included the suspension of all doping-control procedures which applied to both urine and blood samples.

The main reason for the suspension involved analytical techniques relevant to urine analysis; however, the testing of blood samples was also included in the suspension. At the time of the suspension, no adverse findings were reported for the laboratory in relation to blood-sample testing for Athlete Blood Passport (ABP) assessment. 

According to the agreement with WADA, the suspension period would be utilised to implement and test new systems in order to achieve the standard presently required by WADA, as well as to perform development and improvements. SADoCoL is a specialised service laboratory of the UFS and has been in existence for more than thirty years.

Upon SADoCoL’s request to lift the suspension of only the ABP analysis, WADA agreed to allow the laboratory to apply for reaccreditation.  SADoCoL immediately applied for reaccreditation of ABP analysis on blood, so that the laboratory would be allowed to at least offer this service to the Anti-Doping community in Africa.

For this purpose, inspections were performed by the South African National Accreditation System (SANAS) and by WADA, during which all aspects of blood analysis by the laboratory were thoroughly assessed and tested.  The successful outcome of these inspections resulted in the reaccreditation of SADoCoL by WADA in order to perform ABP analysis as required by the WADA International Standard for Laboratories, with effect from 4 August 2016. 

This outcome allows the laboratory to once again perform this very essential analytical procedure.  The South African Institute for Drug-Free Sport (SAIDS) and other regular users can now continue to send blood samples to SADoCoL for ABP analysis, instead of making use of alternative laboratories.

 

Released by: Lacea Loader (Director: Communication and Brand Management)
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