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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

From a dream to a reality: Free State Mother and Child Academic Hospital
2016-08-31

Description: Free State Mother and Child Academic Hospital  Tags: Free State Mother and Child Academic Hospital

The message, From a dream to a reality, echoed
throughout the launch of the Mother and
Child Academic Hospital. From left to right:
Dr Khotso Mokhele, Chancellor of the UFS,
Rolene Strauss, Miss World 2014 and
Patron of the Mother and Child Academic Hospital,
Prof André Venter, Head of the Department of
Paediatrics and Child Health, and Dr Riaan Els,
CEO of the Fuchs Foundation South Africa.
Photo: Charl Devenish

“Sometimes dreams do come true, and finally, this institution is starting to dream big dreams.” These were the words of Dr Khotso Mokhele, Chancellor of the University of the Free State (UFS) at the launch of the Free State Mother and Child Academic Hospital collaborative initiative. The launch was an official declaration of intentions regarding the establishing of the hospital, a specialist unit which will focus on paediatric and maternal healthcare, fully supported by the Department of Health in the Free State. As the first Mother and Child Hospital in South Africa, it will be unique.

Under the leadership of Prof André Venter, the UFS Department of Paediatrics and Child Health serves over 250 000 children of the southern regions of the Free State at secondary care level, and is responsible for the tertiary care of nearly one million children from the whole of the Free State and Northern Cape Provinces, as well as some children from Northwest and Eastern Cape Provinces and Lesotho.

As part of a multi-faceted initiative, the 350-bed mother and child hospital will benefit the community of the Free State greatly, and will support the objectives of the Strategic Development Goals. It will further Free State Strategic Transformation Plan (STP) by improving access to healthcare for the most vulnerable members of the population, thus reducing paediatric mortality and improving maternal health. An additional objective of the project is to develop academic excellence, and improve the environment in which medical specialists and subspecialists develop their skills according to international standards.

Prof Jonathan Jansen, Vice-chancellor and Rector of the UFS, described the project as one which captures the head and the heart, as it caters most for little lives, a hub wherein great talent and potential waits to be unleashed. In support of the project, the university has offered a piece of land on the campus where the hospital will be built, thus strengthening the quality of tertiary education.

Former Miss World, Mrs Rolene Strauss, also pledged her support. She said she is honoured to be the patron of the project, one she believes will lead to healthier women, healthier children, and a healthier nation.

In celebration of the 50th anniversary of the Fuchs Foundation, CEO Dr Riaan Els, awarded a donation of R2250000 towards the building of the hospital, a contribution which will bring the project a step closer to its realisation.

Prof André Venter, leader of the project, hopes that it will serve as a blueprint for other academic hospitals in the country, and mark the beginning of an era of highly specialised medical care for humanity’s most precious people.

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